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Chronic idiopathic thrombocytopenic purpura (ITP): molecular mechanisms and implications for therapy.
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- Andersson, Per-Ola, 1964 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för internmedicin,Institute of Internal Medicine, Dept of Medicine
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- Wadenvik, Hans, 1955 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för internmedicin,Institute of Internal Medicine, Dept of Medicine
- (creator_code:org_t)
- 2004
- 2004
- English.
- In: Expert reviews in molecular medicine. - 1462-3994. ; 6:24, s. 1-17
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- Chronic idiopathic thrombocytopenic purpura (ITP) is an immune-mediated disorder in which platelets are prematurely destroyed in the reticuloendothelial system by platelet autoantibodies. However, it is becoming clear that the pivotal process of the humoral immune response in the pathogenesis of the disorder is a complex interaction between antigen-presenting cells, T cells and B cells. Furthermore, it is increasingly evident that regulatory T cells play an important role and that T-cell-mediated cytotoxicity contributes to the destruction of platelets in ITP. Different new approaches to immunotherapy in chronic ITP have been explored, including use of anti-CD20, anti-CD154 and anti-CD52 antibodies. So far, these therapies have been antigen-nonspecific and the risk of general immunosuppression is a concern. Thus, improving our understanding of the interaction and relative contribution of humoral and cell-mediated mechanisms is essential for developing antigen-specific immunotherapies for the treatment of this disorder. This review aims to elucidate the current status of knowledge of the cellular and humoral immune components of chronic ITP, together with the implications of this knowledge for therapy.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Keyword
- Adult
- Antibodies
- Monoclonal
- immunology
- therapeutic use
- Antigen-Presenting Cells
- immunology
- Antigens
- CD
- immunology
- Antigens
- Human Platelet
- immunology
- Autoantibodies
- immunology
- Blood Platelets
- immunology
- Child
- Humans
- Immune Tolerance
- drug effects
- Immunosuppressive Agents
- therapeutic use
- Immunotherapy
- methods
- Lymphocyte Subsets
- immunology
- Purpura
- Thrombocytopenic
- Idiopathic
- blood
- diagnosis
- immunology
- therapy
Publication and Content Type
- ref (subject category)
- art (subject category)
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