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A variant near the ...
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Andersson, Niklas,1970Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin,Institute of Medicine, Department of Internal Medicine,Chalmers tekniska högskola,Chalmers University of Technology,University of Gothenburg
(author)
A variant near the interleukin-6 gene is associated with fat mass in Caucasian men
- Article/chapterEnglish2010
Publisher, publication year, extent ...
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2010-02-16
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Springer Science and Business Media LLC,2010
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LIBRIS-ID:oai:gup.ub.gu.se/198231
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https://gup.ub.gu.se/publication/198231URI
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https://doi.org/10.1038/ijo.2010.27DOI
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https://lup.lub.lu.se/record/1630999URI
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https://research.chalmers.se/publication/198231URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-125028URI
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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CONTEXT: Regulation of fat mass appears to be associated with immune functions. Studies of knockout mice show that endogenous interleukin (IL)-6 can suppress mature-onset obesity. OBJECTIVE: To systematically investigate associations of single nucleotide polymorphisms (SNPs) near the IL-6 (IL6) and IL-6 receptor (IL6R) genes with body fat mass, in support for our hypothesis that variants of these genes can be associated with obesity. DESIGN AND STUDY SUBJECTS: The Gothenburg Osteoporosis and Obesity Determinants (GOOD) study is a population-based cross-sectional study of 18- to 20-year-old men (n=1049), from the Gothenburg area (Sweden). Major findings were confirmed in two additional cohorts consisting of elderly men from the Osteoporotic Fractures in Men (MrOS) Sweden (n=2851) and MrOS US (n=5611) multicenter population-based studies. MAIN OUTCOME: The genotype distributions and their association with fat mass in different compartments, measured with dual-energy X-ray absorptiometry. RESULTS: Out of 18 evaluated tag SNPs near the IL6 and IL6R genes, a recently identified SNP rs10242595 G/A (minor allele frequency=29%) 3' of the IL6 gene was negatively associated with the primary outcome total body fat mass (effect size -0.11 standard deviation (s.d.) units per A allele, P=0.02). This negative association with fat mass was also confirmed in the combined MrOS Sweden and MrOS US cohorts (effect size -0.05 s.d. units per A allele, P=0.002). When all three cohorts were combined (n=8927, Caucasian subjects), rs10242595(*)A showed a negative association with total body fat mass (effect size -0.05 s.d. units per A allele, P<0.0002). Furthermore, the rs10242595(*)A was associated with low body mass index (effect size -0.03, P<0.001) and smaller regional fat masses. None of the other SNPs investigated in the GOOD study were reproducibly associated with body fat. CONCLUSIONS: The IL6 gene polymorphism rs10242595(*)A is associated with decreased fat mass in three combined cohorts of 8927 Caucasian men.
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Strandberg, Louise,1981Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology(Swepub:gu)xstlou
(author)
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Nilsson, Staffan,1956Gothenburg University,Göteborgs universitet,Institutionen för matematiska vetenskaper, matematisk statistik,Department of Mathematical Sciences, Mathematical Statistics,University of Gothenburg,Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)staffan
(author)
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Adamovic, Svetlana,1965Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk genetik och klinisk genetik,Institute of Biomedicine, Department of Medical and Clinical Genetics,University of Gothenburg(Swepub:gu)xadasv
(author)
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Karlsson, MagnusLund University,Lunds universitet,Ortopedi - klinisk och molekylär osteoporosforskning,Forskargrupper vid Lunds universitet,Orthopedics - Clinical and Molecular Osteoporosis Research,Lund University Research Groups,Skånes universitetssjukhus (SUS),Skåne University Hospital(Swepub:lu)orto-mka
(author)
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Ljunggren, ÖstenUppsala universitet,Institutionen för medicinska vetenskaper,Metabolic Bone Disease(Swepub:uu)osteljun
(author)
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Mellström, Dan,1945Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine,University of Gothenburg(Swepub:gu)xmelda
(author)
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Lane, N. E.University of California
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Zmuda, J. M.University of Pittsburgh
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Nielsen, C.Oregon Health and Science University
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Orwoll, E.Oregon Health and Science University
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Lorentzon, Mattias,1970Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine,University of Gothenburg(Swepub:gu)xlomat
(author)
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Ohlsson, Claes,1965Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine,University of Gothenburg(Swepub:gu)xohlcl
(author)
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Jansson, John-Olov,1954Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology,University of Gothenburg(Swepub:gu)xjanjo
(author)
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Grahnemo, LouiseGöteborgs universitet,University of Gothenburg
(author)
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Göteborgs universitetInstitutionen för medicin, avdelningen för invärtesmedicin
(creator_code:org_t)
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In:International Journal of Obesity: Springer Science and Business Media LLC34:6, s. 1011-90307-05651476-5497
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