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The RING-Finger E3 ...
The RING-Finger E3 Ubiquitin Ligase COP1 SUPPRESSOR1 Negatively Regulates COP1 Abundance in Maintaining COP1 Homeostasis in Dark-Grown Arabidopsis Seedlings
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- Xu, Dongqing (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biologi och miljövetenskap,Department of Biological and Environmental Sciences,University of Gothenburg
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Lin, Fang (author)
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- Yang, Jiang, 1975 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biologi och miljövetenskap,Department of Biological and Environmental Sciences,University of Gothenburg
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Huang, Xi (author)
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Li, Jigang (author)
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Ling, Junjie (author)
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- Hettiarachchi, Chamari (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biologi och miljövetenskap,Department of Biological and Environmental Sciences,University of Gothenburg
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- Tellgren-Roth, Christian (author)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi,Science for Life Laboratory, SciLifeLab
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- Holm, Magnus, 1968 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biologi och miljövetenskap,Department of Biological and Environmental Sciences,University of Gothenburg
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Deng, Xing Wang (author)
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(creator_code:org_t)
- 2014-05-16
- 2014
- English.
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In: The Plant Cell. - : Oxford University Press (OUP). - 1040-4651 .- 1532-298X. ; 26:5, s. 1981-1991
- Related links:
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http://dx.doi.org/10...
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Abstract
Subject headings
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- CONSTITUTIVE PHOTOMORPHOGENIC1 (COP1) functions as an E3 ubiquitin ligase in both plants and animals. In dark-grown Arabidopsis thaliana seedlings, COP1 targets photomorphogenesis-promoting factors for degradation to repress photomorphogenesis. Little is known, however, about how COP1 itself is regulated. Here, we identify COP1 SUPPRESSOR1 (CSU1), a RING-finger E3 ubiquitin ligase, as a regulator of COP1. Genetic evidence demonstrates that csu1 mutations suppress cop1-6 phenotypes completely in the dark. Furthermore, CSU1 colocalizes with COP1 in nuclear speckles and negatively regulates COP1 protein accumulation in darkness. CSU1 can ubiquitinate COP1 in vitro and is essential for COP1 ubiquitination in vivo. Therefore, we conclude that CSU1 plays a major role in maintaining COP1 homeostasis by targeting COP1 for ubiquitination and degradation in dark-grown seedlings.
Subject headings
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Keyword
- LIGHT-DEPENDENT INTERACTION
- PHOTOMORPHOGENIC REPRESSOR COP1
- B-BOX
- PROTEIN
- UV-B
- GENE-EXPRESSION
- BLUE-LIGHT
- CONSTITUTIVELY
- PHOTOMORPHOGENIC1
- MEDIATED DEVELOPMENT
- TUMOR-SUPPRESSOR
- CRYPTOCHROME
- 1
- Biochemistry & Molecular Biology
- Plant Sciences
- Cell Biology
- GENE-EXPRESSION
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Xu, Dongqing
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Lin, Fang
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Yang, Jiang, 197 ...
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Huang, Xi
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Li, Jigang
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Ling, Junjie
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show more...
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Hettiarachchi, C ...
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Tellgren-Roth, C ...
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Holm, Magnus, 19 ...
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Deng, Xing Wang
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Biochemistry and ...
- Articles in the publication
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The Plant Cell
- By the university
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University of Gothenburg
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Chalmers University of Technology
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Uppsala University