Search: onr:"swepub:oai:gup.ub.gu.se/199754" >
The association of ...
The association of apolipoprotein E gene polymorphisms with cerebral palsy in Chinese infants
-
Xu, Y. R. (author)
-
Wang, H. L. (author)
-
Sun, Y. Y. (author)
-
show more...
-
Shang, Q. (author)
-
Chen, M. J. (author)
-
Li, T. C. (author)
-
Zhu, D. N. (author)
-
He, L. (author)
-
- Zhu, Changlian, 1964 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology
-
Xing, Q. H. (author)
-
show less...
-
(creator_code:org_t)
- 2014-02-13
- 2014
- English.
-
In: Molecular Genetics and Genomics. - : Springer Science and Business Media LLC. - 1617-4615 .- 1617-4623. ; 289:3, s. 411-416
- Related links:
-
https://gup.ub.gu.se...
-
show more...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Apolipoprotein E (APOE, protein; ApoE, gene) is a lipid transport protein abundantly present in brain cells. Previous studies have suggested that there is an association between genetic variants of ApoE and susceptibility to cerebral palsy (CP). The purpose of this study was to explore whether the ApoE gene is involved in the etiology of CP in the Chinese population. In this study, 350 CP patients and 242 healthy control children were recruited. Genomic DNA was prepared from venous blood and all five single nucleotide polymorphisms (SNPs) in ApoE (rs769446, rs405509, rs121918399, rs429358, and rs190853081) were detected by the MassARRAY platform-based genotyping approach. The SHEsis program was used to analyze the genotyping data, and we systemically analyzed the association of the ApoE SNPs with different subtypes of CP. No significant association was detected between the e4 identified by the C allele of rs429358 and CP, but there were significant differences in allelic frequencies between the CP patients and controls at rs769446 (P = 0.005, P = 0.025 after Bonferroni correction), as well as between the CP patients with preterm birth (< 34 gestational weeks) and controls at rs769446 (P = 0.001, P = 0.005 after Bonferroni correction). A haplotype consisting of the five SNPs rs769446(C), rs405509(C), rs121918399(C), rs429358(T), and rs190853081(G) was associated with a decreased risk of CP (P = 0.002 after Bonferroni correction). However, we found no significant association between any of the other three SNPs and CP based on different subgroup analyses. This study provides the first evidence that ApoE gene polymorphisms are a potential risk factor for CP in the Chinese population.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Keyword
- Cerebral palsy
- Gene polymorphism
- Mental retardation
- Preterm birth
- Apolipoprotein E
- E GENOTYPE
- ALZHEIMERS-DISEASE
- CANDIDATE GENES
- POPULATION
- CHILDREN
- RISK
- OUTCOMES
- NEURONS
- TERM
- Biochemistry & Molecular Biology
- Genetics & Heredity
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Xu, Y. R.
-
Wang, H. L.
-
Sun, Y. Y.
-
Shang, Q.
-
Chen, M. J.
-
Li, T. C.
-
show more...
-
Zhu, D. N.
-
He, L.
-
Zhu, Changlian, ...
-
Xing, Q. H.
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Cell and Molecul ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Medical Genetics
- Articles in the publication
-
Molecular Geneti ...
- By the university
-
University of Gothenburg