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Meta-analysis of ge...
Meta-analysis of genome-wide association studies identifies two loci associated with circulating osteoprotegerin levels.
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Kwan, Johnny S H (author)
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Hsu, Yi-Hsiang (author)
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Cheung, Ching-Lung (author)
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Dupuis, Josée (author)
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Saint-Pierre, Aude (author)
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- Eriksson, Joel (author)
- Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
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Handelman, Samuel K (author)
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Aragaki, Aaron (author)
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Karasik, David (author)
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Pramstaller, Peter P (author)
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Kooperberg, Charles (author)
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Lacroix, Andrea Z (author)
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Larson, Martin G (author)
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Lau, Kam-Shing (author)
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- Lorentzon, Mattias, 1970 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Centre for Bone and Arthritis Research,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
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Pichler, Irene (author)
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Sham, Pak C (author)
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Taliun, Daniel (author)
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- Vandenput, Liesbeth, 1974 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Centre for Bone and Arthritis Research,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
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Kiel, Douglas P (author)
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Hicks, Andrew A (author)
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Jackson, Rebecca D (author)
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- Ohlsson, Claes, 1965 (author)
- Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
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Benjamin, Emelia J (author)
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Kung, Annie W C (author)
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(creator_code:org_t)
- 2014-07-30
- 2014
- English.
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In: Human Molecular Genetics. - : Oxford University Press (OUP). - 0964-6906 .- 1460-2083. ; 23:24, s. 6684-93
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
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- Osteoprotegerin (OPG) is involved in bone homeostasis and tumor cell survival. Circulating OPG levels are also important biomarkers of various clinical traits, such as cancers and atherosclerosis. OPG levels were measured in serum or in plasma. In a meta-analysis of genome-wide association studies in up to 10,336 individuals from European and Asian origin, we discovered that variants >100 Kb upstream of the TNFRSF11B gene encoding OPG and another new locus on chromosome 17q11.2 were significantly associated with OPG variation. We also identified a suggestive locus on chromosome 14q21.2 associated with the trait. Moreover, we estimated that over half of the heritability of OPG levels could be explained by all variants examined in our study. Our findings provide further insight into the genetic regulation of circulating OPG levels.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Kwan, Johnny S H
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Hsu, Yi-Hsiang
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Cheung, Ching-Lu ...
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Dupuis, Josée
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Saint-Pierre, Au ...
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Eriksson, Joel
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show more...
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Handelman, Samue ...
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Aragaki, Aaron
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Karasik, David
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Pramstaller, Pet ...
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Kooperberg, Char ...
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Lacroix, Andrea ...
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Larson, Martin G
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Lau, Kam-Shing
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Lorentzon, Matti ...
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Pichler, Irene
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Sham, Pak C
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Taliun, Daniel
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Vandenput, Liesb ...
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Kiel, Douglas P
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Hicks, Andrew A
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Jackson, Rebecca ...
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Ohlsson, Claes, ...
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Benjamin, Emelia ...
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Kung, Annie W C
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
- Articles in the publication
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Human Molecular ...
- By the university
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University of Gothenburg