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Can authorities app...
Can authorities appreciably enhance the prescribing of oral generic risperidone to conserve resources? Findings from across Europe and their implications
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- Godman, B. (author)
- Karolinska Institutet
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- Petzold, Max, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa, enheten för arbets-och miljömedicin,Institute of Medicine, Department of Public Health and Community Medicine, Section of Occupational and environmental medicine
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Bennett, K. (author)
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Bennie, M. (author)
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Bucsics, A. (author)
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Finlayson, A. E. (author)
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Martin, A. (author)
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Persson, M. (author)
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Piessnegger, J. (author)
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Raschi, E. (author)
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Simoens, S. (author)
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Zara, C. (author)
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Barbui, C. (author)
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(creator_code:org_t)
- 2014-06-13
- 2014
- English.
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In: Bmc Medicine. - : Springer Science and Business Media LLC. - 1741-7015. ; 12
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Abstract
Subject headings
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- Background: Generic atypical antipsychotic drugs offer health authorities opportunities for considerable savings. However, schizophrenia and bipolar disorders are complex diseases that require tailored treatments. Consequently, generally there have been limited demand-side measures by health authorities to encourage the preferential prescribing of generics. This is unlike the situation with hypertension, hypercholaesterolaemia or acid-related stomach disorders. The objectives of this study were to compare the effect of the limited demand-side measures in Western European countries and regions on the subsequent prescribing of risperidone following generics; to utilise the findings to provide future guidance to health authorities; and where possible, to investigate the utilisation of generic versus originator risperidone and the prices for generic risperidone. Methods: Principally, this was a segmented regression analysis of retrospective time-series data of the effect of the various initiatives in Belgium, Ireland, Scotland and Sweden following the introduction of generic risperidone. The study included patients prescribed at least one atypical antipsychotic drug up to 20 months before and up to 20 months after generic risperidone. In addition, retrospective observational studies were carried out in Austria and Spain (Catalonia) from 2005 to 2011 as well as one English primary care organisation (Bury Primary Care Trust (PCT)). Results: There was a consistent steady reduction in risperidone as a percentage of total selected atypical antipsychotic utilisation following generics. A similar pattern was seen in Austria and Spain, with stable utilisation in one English PCT. However, there was considerable variation in the utilisation of generic risperidone, ranging from 98% of total risperidone in Scotland to only 14% in Ireland. Similarly, the price of generic risperidone varied considerably. In Scotland, generic risperidone was only 16% of pre-patent loss prices versus 72% in Ireland. Conclusion: Consistent findings of no increased prescribing of risperidone post generics with limited specific demand-side measures suggests no 'spillover' effect from one class to another encouraging the preferential prescribing of generic atypical antipsychotic drugs. This is exacerbated by the complexity of the disease area and differences in the side-effects between treatments. There appeared to be no clinical issues with generic risperidone, and prices inversely reflected measures to enhance their utilisation.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Allmänmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- General Practice (hsv//eng)
Keyword
- Generics
- Antipsychotics
- Risperidone
- Demand-side measures
- Drug utilisation
- Cross national study
- ATYPICAL ANTIPSYCHOTIC-DRUGS
- PROTON PUMP INHIBITORS
- BIPOLAR
- DEPRESSION
- MEDICATION USE
- DE-POINTES
- SCHIZOPHRENIA
- EFFICIENCY
- COUNTRIES
- RISK
- METAANALYSIS
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Godman, B.
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Petzold, Max, 19 ...
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Bennett, K.
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Bennie, M.
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Bucsics, A.
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Finlayson, A. E.
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show more...
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Martin, A.
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Persson, M.
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Piessnegger, J.
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Raschi, E.
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Simoens, S.
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Zara, C.
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Barbui, C.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and General Practice
- Articles in the publication
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Bmc Medicine
- By the university
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University of Gothenburg
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Karolinska Institutet