Search: onr:"swepub:oai:gup.ub.gu.se/201906" >
Effects of homocyst...
Effects of homocysteine lowering with B vitamins on cognitive aging: meta-analysis of 11 trials with cognitive data on 22,000 individuals
- Article/chapterEnglish2014
Publisher, publication year, extent ...
Numbers
-
LIBRIS-ID:oai:gup.ub.gu.se/201906
-
https://gup.ub.gu.se/publication/201906URI
-
https://doi.org/10.3945/ajcn.113.076349DOI
Supplementary language notes
Part of subdatabase
Classification
-
Subject category:ref swepub-contenttype
-
Subject category:art swepub-publicationtype
Notes
-
Background: Elevated plasma homocysteine is a risk factor for Alzheimer disease, but the relevance of homocysteine lowering to slow the rate of cognitive aging is uncertain. Objective: The aim was to assess the effects of treatment with B vitamins compared with placebo, when administered for several years, on composite domains of cognitive function, global cognitive function, and cognitive aging. Design: A meta-analysis was conducted by using data combined from 11 large trials in 22,000 participants. Domain-based z scores (for memory, speed, and executive function and a domain-composite score for global cognitive function) were available before and after treatment (mean duration: 2.3 y) in the 4 cognitive-domain trials (1340 individuals); Mini-Mental State Examination (MMSE) type tests were available at the end of treatment (mean duration: 5 y) in the 7 global cognition trials (20,431 individuals). Results: The domain-composite and MMSE-type global cognitive function z scores both decreased with age (mean SE: 0.054 0.004 and 0.036 0.001/y, respectively). Allocation to B vitamins lowered homocysteine concentrations by 28% in the cognitive-domain trials but had no significant effects on the z score differences from baseline for individual domains or for global cognitive function (z score difference: 0.00; 95% CI: 0.05, 0.06). Likewise, allocation to B vitamins lowered homocysteine by 26% in the global cognition trials but also had no significant effect on end-treatment MMSE-type global cognitive function (z score difference: 0.01; 95% CI: 0.03, 0.02). Overall, the effect of a 25% reduction in homocysteine equated to 0.02 y (95% CI: 0.10, 0.13 y) of cognitive aging per year and excluded reductions of >1 mo per year of treatment. Conclusion: Homocysteine lowering by using B vitamins had no significant effect on individual cognitive domains or global cognitive function or on cognitive aging.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Bennett, D.
(author)
-
Parish, S.
(author)
-
Lewington, S.
(author)
-
Skeaff, M.
(author)
-
Eussen, Sjpm
(author)
-
Lewerin, Catharina,1961Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition(Swepub:gu)xlewca
(author)
-
Stott, D. J.
(author)
-
Armitage, J.
(author)
-
Hankey, G. J.
(author)
-
Lonn, E.
(author)
-
Spence, J. D.
(author)
-
Galan, P.
(author)
-
de Groot, L. C.
(author)
-
Halsey, J.
(author)
-
Dangour, A. D.
(author)
-
Collins, R.
(author)
-
Grodstein, F.
(author)
-
Göteborgs universitetInstitutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition
(creator_code:org_t)
Related titles
-
In:American Journal of Clinical Nutrition: Elsevier BV100:2, s. 657-6660002-9165
Internet link
Find in a library
To the university's database
- By the author/editor
-
Clarke, R.
-
Bennett, D.
-
Parish, S.
-
Lewington, S.
-
Skeaff, M.
-
Eussen, Sjpm
-
show more...
-
Lewerin, Cathari ...
-
Stott, D. J.
-
Armitage, J.
-
Hankey, G. J.
-
Lonn, E.
-
Spence, J. D.
-
Galan, P.
-
de Groot, L. C.
-
Halsey, J.
-
Dangour, A. D.
-
Collins, R.
-
Grodstein, F.
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Cardiac and Card ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
- Articles in the publication
-
American Journal ...
- By the university
-
University of Gothenburg