SwePub
Sök i LIBRIS databas

  Extended search

onr:"swepub:oai:gup.ub.gu.se/203589"
 

Search: onr:"swepub:oai:gup.ub.gu.se/203589" > Long-Term Chronic T...

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Long-Term Chronic Toxicity Testing Using Human Pluripotent Stem Cell-Derived Hepatocytes

Holmgren, Gustav (author)
Högskolan i Skövde,Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för klinisk kemi och transfusionsmedicin,Institute of Biomedicine, Department of Clinical Chemistry and Transfusion Medicine,Institutionen för biovetenskap,Forskningscentrum för Systembiologi,Department of Clinical Chemistry and Transfusion Medicine, Institute of Biomedicine, University of Gothenburg, Gothenburg, Sweden,Bioinformatics
Sjögren, Anna-Karin, 1980 (author)
Department of Discovery Safety, Drug Safety and Metabolism, AstraZeneca RandD, Mölndal, Sweden
Barragan, I. (author)
Karolinska Institutet,Section of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
show more...
Sabirsh, A. (author)
Department of Bioscience, Cardiovascular and Metabolic Diseases, AstraZeneca RandD, Mölndal, Sweden
Synnergren, Jane, 1967 (author)
Högskolan i Skövde,Institutionen för biovetenskap,Forskningscentrum för Systembiologi,Bioinformatics
Bjorquist, P. (author)
NovaHep AB, Gothenburg, Sweden / Cellectis AB, Gothenburg, Sweden
Ingelman-Sundberg, M. (author)
Karolinska Institutet,Section of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
Andersson, B Tommy, 1964 (author)
Section of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden / Department of Drug Metabolism and Pharmacokinetics, AstraZeneca RandD, Mölndal, Sweden
Edsbagge, Josefina, 1973 (author)
Cellectis AB, Gothenburg, Sweden
Sartipy, Peter (author)
Högskolan i Skövde,Institutionen för biovetenskap,Forskningscentrum för Systembiologi,Cellectis AB, Gothenburg, Sweden,Bioinformatics
show less...
 (creator_code:org_t)
2014-06-30
2014
English.
In: Drug Metabolism and Disposition. - : American Society for Pharmacology & Experimental Therapeutics (ASPET). - 0090-9556 .- 1521-009X. ; 42:9, s. 1401-1406
Related links:
https://gup.ub.gu.se...
show more...
https://doi.org/10.1...
http://kipublication...
https://urn.kb.se/re...
show less...
  • Journal article (peer-reviewed)
Abstract Subject headings
Close  
  • Human pluripotent stem cells (hPSC) have the potential to become important tools for the establishment of new models for in vitro drug testing of, for example, toxicity and pharmacological effects. Late-stage attrition in the pharmaceutical industry is to a large extent caused by selection of drug candidates using nonpredictive preclinical models that are not clinically relevant. The current hepatic in vivo and in vitro models show clear limitations, especially for studies of chronic hepatotoxicity. For these reasons, we evaluated the potential of using hPSC-derived hepatocytes for long-term exposure to toxic drugs. The differentiated hepatocytes were incubated with hepatotoxic compounds for up to 14 days, using a repeated-dose approach. The hPSC-derived hepatocytes became more sensitive to the toxic compounds after extended exposures and, in addition to conventional cytotoxicity, evidence of phospholipidosis and steatosis was also observed in the cells. This is, to the best of our knowledge, the first report of a long-term toxicity study using hPSC-derived hepatocytes, and the observations support further development and validation of hPSC-based toxicity models for evaluating novel drugs, chemicals, and cosmetics.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinsk bioteknologi -- Medicinsk bioteknologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Medical Biotechnology -- Medical Biotechnology (hsv//eng)

Keyword

INDUCED LIVER-INJURY
DIRECT THROMBIN INHIBITOR
HUMAN HEPATOMA-CELL
IN-VITRO MODEL
HEPARG CELLS
DRUG-METABOLISM
CYTOCHROMES P450
HEPG2
CELLS
XIMELAGATRAN
HEPATOTOXICITY
Pharmacology & Pharmacy
Bioinformatik

Publication and Content Type

ref (subject category)
art (subject category)

Find in a library

To the university's database

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view