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The impact of eleva...
The impact of elevated serum IgG4 levels in patients with primary sclerosing cholangitis
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- Benito de Valle, Maria (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine
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Muller, T. (author)
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Bjornsson, E. (author)
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Otten, M. (author)
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Volkmann, M. (author)
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Guckelberger, O. (author)
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Wiedenmann, B. (author)
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- Sadik, Riadh, 1963 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine
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Schott, E. (author)
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Andersson, M. (author)
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Berg, T. (author)
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- Lindkvist, Björn (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine
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(creator_code:org_t)
- Elsevier BV, 2014
- 2014
- English.
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In: Digestive and Liver Disease. - : Elsevier BV. - 1590-8658. ; 46:10, s. 903-908
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Abstract
Subject headings
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- Background: Elevated IgG4 levels have been reported among patients with primary sclerosing cholangitis. Epidemiological data has only been provided from tertiary centres. Aims: To investigate the prevalence of elevated IgG4 levels and to compare prognosis between patients with and without elevated IgG4 levels in serum in two European cohorts of patients with primary sclerosing cholangitis. Methods: Serum IgG4-levels were measured in a consecutive series of patients from Berlin, and retrospectively collected in a population-based cohort from Sweden (total N = 345). Cox's proportional hazard analysis was used to calculate relative risks for liver-related death or liver transplantation and cholangiocarcinoma. Results: Elevated IgG4 values were demonstrated in 10% of patients. A previous history of pancreatitis, combined intra-and extrahepatic biliary involvement and jaundice were independently associated with elevated IgG4 in multivariate analysis. IgG4 status was not associated with an increased risk for the combined endpoint liver-related death or liver transplantation or cholangiocarcinoma. Conclusion: The prevalence of elevated IgG4 values among European patients with primary sclerosing cholangitis is similar to what previously has been reported from the United States. Elevated IgG4 was not associated with an increased risk of liver transplantation or liver-related death or cholangiocarcinoma.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Keyword
- IgG4 status
- Prevalence
- Survival
- IMMUNOGLOBULIN G4-ASSOCIATED CHOLANGITIS
- THERAPY
- SPECTRUM
- G4
- Gastroenterology & Hepatology
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Benito de Valle, ...
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Muller, T.
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Bjornsson, E.
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Otten, M.
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Volkmann, M.
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Guckelberger, O.
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show more...
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Wiedenmann, B.
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Sadik, Riadh, 19 ...
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Schott, E.
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Andersson, M.
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Berg, T.
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Lindkvist, Björn
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
- Articles in the publication
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Digestive and Li ...
- By the university
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University of Gothenburg