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- Durazzo, T. C. (author)
History of cigarette smoking in cognitively-normal elders is associated with elevated cerebrospinal fluid biomarkers of oxidative stress
- Article/chapterEnglish2014
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- Elsevier BV,2014
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- LIBRIS-ID:oai:gup.ub.gu.se/204217
- https://gup.ub.gu.se/publication/204217URI
- https://doi.org/10.1016/j.drugalcdep.2014.06.030DOI
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- Language:English
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- Background: Cigarette smoking in adults is associated with abnormalities in brain neurobiology. Smoking-induced central nervous system oxidative stress (OxS) is a potential mechanism associated with these abnormalities. The goal of this study was to compare cognitively-normal elders on cerebrospinal fluid (CSF) levels of F-2-isoprostane biomarkers of OxS. Methods: Elders with a lifetime history of smoking (smokers; n = 50; 75 +/- 5 years of age; 34 +/- 28 pack-years; approximately 12% were actively smoking at the time of study) were compared to never-smokers (n = 61; 76 +/- 6 years of age) on CSF iPF(2 alpha)-III and 8,12, iso-iPF(2 alpha)-VI F-2-isoprostanes levels. F-2-isoprostanes levels were quantitated with HPLC-atmospheric pressure chemical ionization-tandem mass spectrometry. Associations between F-2-isoprostanes levels, hippocampal volumes, and cigarette exposure measures were also evaluated. Results: Smokers showed higher iPF(2 alpha)-III level than never-smokers. An age x smoking status interaction was observed for 8,12, iso-iPF(2 alpha)-VI, where smokers demonstrate a significantly greater concentration with increasing age than never-smokers. In smokers only, higher 8,12, iso-iPF(2 alpha)-VI concentration was associated with smaller hippocampal volume, and greater iPF(2 alpha)-III level was related to greater pack years. Conclusions: This is the first study to demonstrate that a history of cigarette smoking in cognitively-normal elders was associated with significantly elevated CSF F-2-isoprostane levels and greater age-related increases in F-2-isoprostanes, and that higher F-2-isoprostane levels in smokers were related to smaller hippocampal volume. These findings provide additional novel evidence that a history of chronic smoking during adulthood is associated with adverse effects on the human brain that are potentially enduring even with extended smoking cessation.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine hsv//eng
- Cigarette smoking
- Oxidative stress
- Isoprostanes
- Hippocampus
- Cerebrospinal fluid
- Elder adults
- SURFACE-BASED ANALYSIS
- HUMAN CEREBRAL-CORTEX
- ALZHEIMERS-DISEASE
- TOBACCO-SMOKE
- CARDIOVASCULAR-DISEASE
- LIPID-PEROXIDATION
- UNITED-STATES
- HUMAN URINE
- RISK-FACTOR
- BACOSIDE-A
- Substance Abuse
- Psychiatry
Added entries (persons, corporate bodies, meetings, titles ...)
- Mattsson, Niklas,1979Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology(Swepub:gu)xmattn (author)
- Weiner, M. W. (author)
- Korecka, M. (author)
- Trojanowski, J. Q. (author)
- Shaw, L. M. (author)
- Göteborgs universitetInstitutionen för neurovetenskap och fysiologi (creator_code:org_t)
Related titles
- In:Drug and Alcohol Dependence: Elsevier BV142, s. 262-2680376-8716
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