Leukocyte telomere length is not associated with mortality in older men

Svensson, Johan,1964Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research (author)

Leukocyte telomere length (LTL) is related to the aging of somatic cells. We hypothesized that LTL is inversely associated with mortality in elderly men. LTL was measured in 2744 elderly men (mean age 75.5, range 69-81 years) included in the prospective population-based MrOS-Sweden study. Mortality data were obtained from national health registers with no loss of follow-up. During the follow-up (mean 6.0 years), 556 (20%) of the participants died. Using Cox proportional hazards regression, tertile of LTL did not associate with all-cause mortality [tertile 1 (shortest) or 2 (middle) vs. tertile 3 (longest); hazard ratio (HR) = 1.05, 95% confidence interval (CI) 0.85-1.28 and HR = 0.97, 95% CI 0.79-1.19, respectively]. Furthermore, LTL did not associate with cancer (197 events) or cardiovascular disease (CVD, 206 events) mortality (tertile 1 vs. tertile 3; HR = 0.94, 95% CI 0.67-1.34 and HR = 0.94, 95% CI 0.68-1.30, respectively). The lack of association between LTL and mortality remained also after adjustment for multiple covariates. Our results demonstrate that LTL is not associated with all-cause mortality or mortality due to cancer or CVD in elderly men. Further studies are needed to determine whether LTL can predict the risk of mortality in elderly women.

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Annan medicin och hälsovetenskap Gerontologi, medicinsk/hälsovetenskaplig inriktning hsv//swe
MEDICAL AND HEALTH SCIENCES Other Medical and Health Sciences Gerontology, specialising in Medical and Health Sciences hsv//eng
Leukocyte telomere length
Elderly men
All-cause mortality
Cancer mortality
Cardiovascular
CORONARY-HEART-DISEASE
CARDIOVASCULAR HEALTH
LONGITUDINAL FINDINGS
CANCER-MORTALITY
INCIDENT CANCER
SOUTHERN BLOTS
ELDERLY-MEN
SURVIVAL
AGE
DEMENTIA
Geriatrics & Gerontology
Leukocyte telomere length

Karlsson, MagnusLund University,Lunds universitet,Ortopedi - klinisk och molekylär osteoporosforskning,Forskargrupper vid Lunds universitet,Orthopedics - Clinical and Molecular Osteoporosis Research,Lund University Research Groups(Swepub:lu)orto-mka (author)
Ljunggren, ÖstenUppsala universitet,Endokrinologi och mineralmetabolism(Swepub:uu)osteljun (author)
Tivesten, Åsa,1969Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory(Swepub:gu)xtivas (author)
Mellström, Dan,1945Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research(Swepub:gu)xmelda (author)
Movérare-Skrtic, SofiaGothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research(Swepub:gu)xmovso (author)
Göteborgs universitetCentre for Bone and Arthritis Research (creator_code:org_t)

By the author/editor: Svensson, Johan, ...; Karlsson, Magnus; Ljunggren, Östen; Tivesten, Åsa, 1 ...; Mellström, Dan, ...; Movérare-Skrtic, ...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Other Medical an ...; and Gerontology spec ...

By the university: University of Gothenburg; Lund University; Uppsala University

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