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The PNPLA3 I148M va...
The PNPLA3 I148M variant and chronic liver disease: When a genetic mutation meets nutrients
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- Maglio, Cristina, 1983 (author)
- Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberg Laboratory,Institute of Medicine, Department of Molecular and Clinical Medicine
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- Pirazzi, Carlo (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberglaboratoriet,Institute of Medicine, Department of Molecular and Clinical Medicine,Wallenberg Laboratory
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Pujia, A. (author)
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Valenti, L. (author)
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- Romeo, Stefano, 1976 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberglaboratoriet,Institute of Medicine, Department of Molecular and Clinical Medicine,Wallenberg Laboratory
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(creator_code:org_t)
- Elsevier BV, 2014
- 2014
- English.
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In: Food Research International. - : Elsevier BV. - 0963-9969. ; 63, s. 239-243
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Abstract
Subject headings
Close
- The isoleucine to methionine substitution at position 148 in the patatin-like phospholipase domain containing 3 protein (PNPLA3; I148M variant, rs738409) is associated with liver fat accumulation and an increased risk of chronic liver disease ranging from hepatitis to hepatocellular carcinoma. This review discusses the interaction between the PNPLA3 I148M variant and obesity/intake of specific nutrients in determining the susceptibility to liver disease. We present the results of several studies showing that obesity or alcohol abuse enhances the effect of the PNPLA3 I148M variant on the liver. We also show that specific nutrients interact with the PNPLA3 I148M variant in modulating liver disease susceptibility. (C) 2014 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Keyword
- PNPLA3 rs738409
- Adiponutrin
- Nutrigenetics
- Obesity
- Liver steatosis
- DOMAIN-CONTAINING 3
- CHRONIC HEPATITIS-C
- FATTY LIVER
- HEPATOCELLULAR-CARCINOMA
- HEREDITARY HEMOCHROMATOSIS
- ALCOHOL INTAKE
- CHILDHOOD BMI
- WEIGHT-LOSS
- RISK
- STEATOSIS
- Food Science & Technology
Publication and Content Type
- ref (subject category)
- art (subject category)
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