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The risk-associated...
The risk-associated long noncoding RNA NBAT-1 controls neuroblastoma progression by regulating cell proliferation and neuronal differentiation.
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- Pandey, Gaurav Kumar (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk genetik och klinisk genetik,Institute of Biomedicine, Department of Medical and Clinical Genetics,University of Gothenburg,Department of Medical Genetics, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Sweden
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- Mitra, Sanhita (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk genetik och klinisk genetik,Institute of Biomedicine, Department of Medical and Clinical Genetics,University of Gothenburg,Department of Medical Genetics, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Sweden
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- Subhash, Santhilal, 1987 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk genetik och klinisk genetik,Institute of Biomedicine, Department of Medical and Clinical Genetics,University of Gothenburg,Department of Medical Genetics, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Sweden
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- Hertwig, Falk (author)
- Department of Pediatric Hematology and Oncology, University Children’s Hospital of Cologne, and Center for Molecular Medicine Cologne, University of Cologne, Germany
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- Kanduri, Meena, 1974 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för klinisk kemi och transfusionsmedicin,Institute of Biomedicine, Department of Clinical Chemistry and Transfusion Medicine,University of Gothenburg,Department of Clinical Chemistry and Transfusion Medicine, Institute of Biomedicine, University of Gothenburg, Sweden
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- Mishra, Kankadeb, 1981 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk genetik och klinisk genetik,Institute of Biomedicine, Department of Medical and Clinical Genetics,University of Gothenburg,Department of Medical Genetics, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Sweden
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- Fransson, Susanne, 1975 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk genetik och klinisk genetik,Institute of Biomedicine, Department of Medical and Clinical Genetics,University of Gothenburg,Department of Clinical Genetics, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Sweden
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- Ganeshram, Abiarchana (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk genetik och klinisk genetik,Institute of Biomedicine, Department of Medical and Clinical Genetics,University of Gothenburg,Department of Medical Genetics, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Sweden
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- Mondal, Tanmoy, 1981 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk genetik och klinisk genetik,Institute of Biomedicine, Department of Medical and Clinical Genetics,University of Gothenburg,Department of Medical Genetics, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Sweden
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- Bandaru, Sashidar (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology,University of Gothenburg,Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Sweden
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- Östensson, Malin, 1984 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk genetik och klinisk genetik,Institute of Biomedicine, Department of Medical and Clinical Genetics,University of Gothenburg,Department of Clinical Genetics, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Sweden
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- Akyürek, Levent, 1966 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology,University of Gothenburg,Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Sweden
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- Abrahamsson, Jonas, 1954 (author)
- Department of Pediatrics, The Queen Silvia Children’s Hospital, Sweden
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- Pfeifer, Susan, 1948- (author)
- Uppsala universitet,Pediatrik,Barnonkologisk forskning/Pfeifer
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- Larsson, Erik, 1975 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology,University of Gothenburg,Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Sweden
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- Shi, Leming (author)
- School of Pharmacy, Fudan University, Shanghai, China
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- Peng, Zhiyu (author)
- BGI-Guangzhou, China
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- Fischer, Matthias (author)
- Department of Pediatric Hematology and Oncology, University Children’s Hospital of Cologne, and Center for Molecular Medicine Cologne, University of Cologne, Germany
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- Martinsson, Tommy, 1956 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk genetik och klinisk genetik,Institute of Biomedicine, Department of Medical and Clinical Genetics,University of Gothenburg,Department of Clinical Genetics, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Sweden
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- Hedborg, Fredrik, 1950- (author)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa,Barnonkologisk forskning/Pfeifer
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- Kogner, Per (author)
- Karolinska Institutet
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- Kanduri, Chandrasekhar, 1967 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk genetik och klinisk genetik,Institute of Biomedicine, Department of Medical and Clinical Genetics,University of Gothenburg,Department of Medical Genetics, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Sweden
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(creator_code:org_t)
- Elsevier BV, 2014
- 2014
- English.
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In: Cancer Cell. - : Elsevier BV. - 1535-6108 .- 1878-3686. ; 26:5, s. 722-737
- Related links:
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http://www.cell.com/...
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http://dx.doi.org/10...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://research.cha...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Subject headings
Close
- Neuroblastoma is an embryonal tumor of the sympathetic nervous system and the most common extracranial tumor of childhood. By sequencing transcriptomes of low- and high-risk neuroblastomas, we detected differentially expressed annotated and nonannotated long noncoding RNAs (lncRNAs). We identified a lncRNA neuroblastoma associated transcript-1 (NBAT-1) as a biomarker significantly predicting clinical outcome of neuroblastoma. CpG methylation and a high-risk neuroblastoma associated SNP on chromosome 6p22 functionally contribute to NBAT-1 differential expression. Loss of NBAT-1 increases cellular proliferation and invasion. It controls these processes via epigenetic silencing of target genes. NBAT-1 loss affects neuronal differentiation through activation of the neuronal-specific transcription factor NRSF/REST. Thus, loss of NBAT-1 contributes to aggressive neuroblastoma by increasing proliferation and impairing differentiation of neuronal precursors.
Subject headings
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- NBAT-1
- NBAT1
- NBAT
- Neuroblastoma
- long noncoding RNA
- Epigenetics
- NBAT-1
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Pandey, Gaurav K ...
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Mitra, Sanhita
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Subhash, Santhil ...
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Hertwig, Falk
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Kanduri, Meena, ...
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Mishra, Kankadeb ...
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show more...
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Fransson, Susann ...
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Ganeshram, Abiar ...
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Mondal, Tanmoy, ...
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Bandaru, Sashida ...
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Östensson, Malin ...
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Akyürek, Levent, ...
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Abrahamsson, Jon ...
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Pfeifer, Susan, ...
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Larsson, Erik, 1 ...
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Shi, Leming
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Peng, Zhiyu
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Fischer, Matthia ...
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Martinsson, Tomm ...
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Hedborg, Fredrik ...
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Kogner, Per
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Kanduri, Chandra ...
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Biochemistry and ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Cancer Cell
- By the university
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University of Gothenburg
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Chalmers University of Technology
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Uppsala University
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Karolinska Institutet