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The risk-associated long noncoding RNA NBAT-1 controls neuroblastoma progression by regulating cell proliferation and neuronal differentiation.

Pandey, Gaurav Kumar (author)
Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk genetik och klinisk genetik,Institute of Biomedicine, Department of Medical and Clinical Genetics,University of Gothenburg,Department of Medical Genetics, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Sweden
Mitra, Sanhita (author)
Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk genetik och klinisk genetik,Institute of Biomedicine, Department of Medical and Clinical Genetics,University of Gothenburg,Department of Medical Genetics, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Sweden
Subhash, Santhilal, 1987 (author)
Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk genetik och klinisk genetik,Institute of Biomedicine, Department of Medical and Clinical Genetics,University of Gothenburg,Department of Medical Genetics, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Sweden
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Hertwig, Falk (author)
Department of Pediatric Hematology and Oncology, University Children’s Hospital of Cologne, and Center for Molecular Medicine Cologne, University of Cologne, Germany
Kanduri, Meena, 1974 (author)
Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för klinisk kemi och transfusionsmedicin,Institute of Biomedicine, Department of Clinical Chemistry and Transfusion Medicine,University of Gothenburg,Department of Clinical Chemistry and Transfusion Medicine, Institute of Biomedicine, University of Gothenburg, Sweden
Mishra, Kankadeb, 1981 (author)
Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk genetik och klinisk genetik,Institute of Biomedicine, Department of Medical and Clinical Genetics,University of Gothenburg,Department of Medical Genetics, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Sweden
Fransson, Susanne, 1975 (author)
Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk genetik och klinisk genetik,Institute of Biomedicine, Department of Medical and Clinical Genetics,University of Gothenburg,Department of Clinical Genetics, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Sweden
Ganeshram, Abiarchana (author)
Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk genetik och klinisk genetik,Institute of Biomedicine, Department of Medical and Clinical Genetics,University of Gothenburg,Department of Medical Genetics, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Sweden
Mondal, Tanmoy, 1981 (author)
Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk genetik och klinisk genetik,Institute of Biomedicine, Department of Medical and Clinical Genetics,University of Gothenburg,Department of Medical Genetics, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Sweden
Bandaru, Sashidar (author)
Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology,University of Gothenburg,Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Sweden
Östensson, Malin, 1984 (author)
Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk genetik och klinisk genetik,Institute of Biomedicine, Department of Medical and Clinical Genetics,University of Gothenburg,Department of Clinical Genetics, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Sweden
Akyürek, Levent, 1966 (author)
Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology,University of Gothenburg,Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Sweden
Abrahamsson, Jonas, 1954 (author)
Department of Pediatrics, The Queen Silvia Children’s Hospital, Sweden
Pfeifer, Susan, 1948- (author)
Uppsala universitet,Pediatrik,Barnonkologisk forskning/Pfeifer
Larsson, Erik, 1975 (author)
Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology,University of Gothenburg,Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Sweden
Shi, Leming (author)
School of Pharmacy, Fudan University, Shanghai, China
Peng, Zhiyu (author)
BGI-Guangzhou, China
Fischer, Matthias (author)
Department of Pediatric Hematology and Oncology, University Children’s Hospital of Cologne, and Center for Molecular Medicine Cologne, University of Cologne, Germany
Martinsson, Tommy, 1956 (author)
Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk genetik och klinisk genetik,Institute of Biomedicine, Department of Medical and Clinical Genetics,University of Gothenburg,Department of Clinical Genetics, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Sweden
Hedborg, Fredrik, 1950- (author)
Uppsala universitet,Institutionen för kvinnors och barns hälsa,Barnonkologisk forskning/Pfeifer
Kogner, Per (author)
Karolinska Institutet
Kanduri, Chandrasekhar, 1967 (author)
Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk genetik och klinisk genetik,Institute of Biomedicine, Department of Medical and Clinical Genetics,University of Gothenburg,Department of Medical Genetics, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Sweden
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 (creator_code:org_t)
Elsevier BV, 2014
2014
English.
In: Cancer Cell. - : Elsevier BV. - 1535-6108 .- 1878-3686. ; 26:5, s. 722-737
  • Journal article (peer-reviewed)
Abstract Subject headings
Close  
  • Neuroblastoma is an embryonal tumor of the sympathetic nervous system and the most common extracranial tumor of childhood. By sequencing transcriptomes of low- and high-risk neuroblastomas, we detected differentially expressed annotated and nonannotated long noncoding RNAs (lncRNAs). We identified a lncRNA neuroblastoma associated transcript-1 (NBAT-1) as a biomarker significantly predicting clinical outcome of neuroblastoma. CpG methylation and a high-risk neuroblastoma associated SNP on chromosome 6p22 functionally contribute to NBAT-1 differential expression. Loss of NBAT-1 increases cellular proliferation and invasion. It controls these processes via epigenetic silencing of target genes. NBAT-1 loss affects neuronal differentiation through activation of the neuronal-specific transcription factor NRSF/REST. Thus, loss of NBAT-1 contributes to aggressive neuroblastoma by increasing proliferation and impairing differentiation of neuronal precursors.

Subject headings

NATURVETENSKAP  -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
NATURAL SCIENCES  -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

Keyword

NBAT-1
NBAT1
NBAT
Neuroblastoma
long noncoding RNA
Epigenetics
NBAT-1

Publication and Content Type

ref (subject category)
art (subject category)

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