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GlycoDigest: a tool...
GlycoDigest: a tool for the targeted use of exoglycosidase digestions in glycan structure determination
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Gotz, L. (author)
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Abrahams, J. L. (author)
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Mariethoz, J. (author)
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Rudd, P. M. (author)
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- Karlsson, Niclas G., 1966 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology
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Packer, N. H. (author)
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Campbell, M. P. (author)
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Lisacek, F. (author)
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(creator_code:org_t)
- 2014-07-10
- 2014
- English.
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In: Bioinformatics. - : Oxford University Press (OUP). - 1367-4803 .- 1367-4811. ; 30:21, s. 3131-3133
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https://academic.oup...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Sequencing oligosaccharides by exoglycosidases, either sequentially or in an array format, is a powerful tool to unambiguously determine the structure of complex N- and O-link glycans. Here, we introduce GlycoDigest, a tool that simulates exoglycosidase digestion, based on controlled rules acquired from expert knowledge and experimental evidence available in GlycoBase. The tool allows the targeted design of glycosidase enzyme mixtures by allowing researchers to model the action of exoglycosidases, thereby validating and improving the efficiency and accuracy of glycan analysis.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
- NATURVETENSKAP -- Data- och informationsvetenskap -- Bioinformatik (hsv//swe)
- NATURAL SCIENCES -- Computer and Information Sciences -- Bioinformatics (hsv//eng)
Keyword
- Biochemical Research Methods
- Biotechnology & Applied Microbiology
- Computer Science
- Interdisciplinary Applications
- Computational Biology
- Statistics & Probability
Publication and Content Type
- ref (subject category)
- art (subject category)
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