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Urinary sodium and ...
Urinary sodium and potassium excretion, mortality, and cardiovascular events
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O'Donnell, M. (author)
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Mente, A. (author)
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Rangarajan, S. (author)
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McQueen, M. J. (author)
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Wang, X. (author)
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Liu, L. (author)
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Yan, H. (author)
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Lee, S. F. (author)
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Mony, P. (author)
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Devanath, A. (author)
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- Rosengren, Annika, 1951 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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Lopez-Jaramillo, P. (author)
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Diaz, R. (author)
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Avezum, A. (author)
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Lanas, F. (author)
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Yusoff, K. (author)
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Iqbal, R. (author)
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Ilow, R. (author)
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Mohammadifard, N. (author)
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Gulec, S. (author)
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Yusufali, A. H. (author)
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Kruger, L. (author)
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Yusuf, R. (author)
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Chifamba, J. (author)
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Kabali, C. (author)
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Dagenais, G. (author)
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Lear, S. A. (author)
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Teo, K. (author)
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Yusuf, S. (author)
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(creator_code:org_t)
- 2014
- 2014
- English.
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In: New England Journal of Medicine. - 0028-4793 .- 1533-4406. ; 371:7, s. 612-623
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https://doi.org/10.1...
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Abstract
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- BACKGROUND: The optimal range of sodium intake for cardiovascular health is controversial. METHODS: We obtained morning fasting urine samples from 101,945 persons in 17 countries and estimated 24-hour sodium and potassium excretion (used as a surrogate for intake). We examined the association between estimated urinary sodium and potassium excretion and the composite outcome of death and major cardiovascular events. RESULTS: The mean estimated sodium and potassium excretion was 4.93 g per day and 2.12 g per day, respectively. With a mean follow-up of 3.7 years, the composite outcome occurred in 3317 participants (3.3%). As compared with an estimated sodium excretion of 4.00 to 5.99 g per day (reference range), a higher estimated sodium excretion (>/= 7.00 g per day) was associated with an increased risk of the composite outcome (odds ratio, 1.15; 95% confidence interval [CI], 1.02 to 1.30), as well as increased risks of death and major cardiovascular events considered separately. The association between a high estimated sodium excretion and the composite outcome was strongest among participants with hypertension (P=0.02 for interaction), with an increased risk at an estimated sodium excretion of 6.00 g or more per day. As compared with the reference range, an estimated sodium excretion that was below 3.00 g per day was also associated with an increased risk of the composite outcome (odds ratio, 1.27; 95% CI, 1.12 to 1.44). As compared with an estimated potassium excretion that was less than 1.50 g per day, higher potassium excretion was associated with a reduced risk of the composite outcome. CONCLUSIONS: In this study in which sodium intake was estimated on the basis of measured urinary excretion, an estimated sodium intake between 3 g per day and 6 g per day was associated with a lower risk of death and cardiovascular events than was either a higher or lower estimated level of intake. As compared with an estimated potassium excretion that was less than 1.50 g per day, higher potassium excretion was associated with a lower risk of death and cardiovascular events. (Funded by the Population Health Research Institute and others.).
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Keyword
- Adult
- Cardiovascular Diseases/*epidemiology/etiology
- *Diet
- Female
- Follow-Up Studies
- Humans
- Linear Models
- Male
- Middle Aged
- *Mortality
- Potassium/administration & dosage/*urine
- Sodium/*urine
- Sodium
- Dietary/*administration & dosage/adverse effects
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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O'Donnell, M.
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Mente, A.
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Rangarajan, S.
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McQueen, M. J.
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Wang, X.
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Liu, L.
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show more...
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Yan, H.
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Lee, S. F.
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Mony, P.
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Devanath, A.
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Rosengren, Annik ...
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Lopez-Jaramillo, ...
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Diaz, R.
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Avezum, A.
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Lanas, F.
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Yusoff, K.
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Iqbal, R.
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Ilow, R.
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Mohammadifard, N ...
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Gulec, S.
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Yusufali, A. H.
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Kruger, L.
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Yusuf, R.
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Chifamba, J.
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Kabali, C.
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Dagenais, G.
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Lear, S. A.
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Teo, K.
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Yusuf, S.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
- Articles in the publication
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New England Jour ...
- By the university
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University of Gothenburg