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Biomarker time out
Biomarker time out
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Petzold, A. (author)
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Bowser, R. (author)
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Calabresi, P. (author)
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- Zetterberg, Henrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Uitdehaag, B. M. J. (author)
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(creator_code:org_t)
- 2014-02-20
- 2014
- English.
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In: Multiple Sclerosis Journal. - : SAGE Publications. - 1352-4585 .- 1477-0970. ; 20:12, s. 1560-1563
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Subject headings
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- The advancement of knowledge relies on scientific investigations. The timing between asking a question and data collection defines if a study is prospective or retrospective. Prospective studies look forward from a point in time, are less prone to bias and are considered superior to retrospective studies. This conceptual framework conflicts with the nature of biomarker research. New candidate biomarkers are discovered in a retrospective manner. There are neither resources nor time for prospective testing in all cases. Relevant sources for bias are not covered. Ethical questions arise through the time penalty of an overly dogmatic concept. The timing of sample collection can be separated from testing biomarkers. Therefore the moment of formulating a hypothesis may be after sample collection was completed. A conceptual framework permissive to asking research questions without the obligation to bow to the human concept of calendar time would simplify biomarker research, but will require new safeguards against bias.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- Biomarker study design
- bias
- multiple sclerosis
- Alzheimer disease
- Parkinson syndrome
- traumatic
- CEREBROSPINAL-FLUID
- PARKINSONS-DISEASE
- ALPHA-SYNUCLEIN
- MULTIPLE-SCLEROSIS
- ALZHEIMER-DISEASE
- PROTEOMICS
- UTILITY
- CSF
- Clinical Neurology
Publication and Content Type
- ref (subject category)
- art (subject category)
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