Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins.

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Postmus, Iris (author)

Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins.

Article/chapterEnglish2014

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2014-10-28
Springer Science and Business Media LLC,2014

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LIBRIS-ID:oai:gup.ub.gu.se/207817
https://gup.ub.gu.se/publication/207817URI
https://doi.org/10.1038/ncomms6068DOI
https://lup.lub.lu.se/record/4733012URI

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Language:English

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

Statins effectively lower LDL cholesterol levels in large studies and the observed interindividual response variability may be partially explained by genetic variation. Here we perform a pharmacogenetic meta-analysis of genome-wide association studies (GWAS) in studies addressing the LDL cholesterol response to statins, including up to 18,596 statin-treated subjects. We validate the most promising signals in a further 22,318 statin recipients and identify two loci, SORT1/CELSR2/PSRC1 and SLCO1B1, not previously identified in GWAS. Moreover, we confirm the previously described associations with APOE and LPA. Our findings advance the understanding of the pharmacogenetic architecture of statin response.

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Trompet, Stella (author)
Deshmukh, Harshal A (author)
Barnes, Michael R (author)
Li, Xiaohui (author)
Warren, Helen R (author)
Chasman, Daniel I (author)
Zhou, Kaixin (author)
Arsenault, Benoit J (author)
Donnelly, Louise A (author)
Wiggins, Kerri L (author)
Avery, Christy L (author)
Griffin, Paula (author)
Feng, QiPing (author)
Taylor, Kent D (author)
Li, Guo (author)
Evans, Daniel S (author)
Smith, Albert V (author)
de Keyser, Catherine E (author)
Johnson, Andrew D (author)
de Craen, Anton J M (author)
Stott, David J (author)
Buckley, Brendan M (author)
Ford, Ian (author)
Westendorp, Rudi G J (author)
Eline Slagboom, P (author)
Sattar, Naveed (author)
Munroe, Patricia B (author)
Sever, Peter (author)
Poulter, Neil (author)
Stanton, Alice (author)
Shields, Denis C (author)
O'Brien, Eoin (author)
Shaw-Hawkins, Sue (author)
Ida Chen, Y-D (author)
Nickerson, Deborah A (author)
Smith, Joshua D (author)
Pierre Dubé, Marie (author)
Matthijs Boekholdt, S (author)
Kees Hovingh, G (author)
Kastelein, John J P (author)
McKeigue, Paul M (author)
Betteridge, John (author)
Neil, Andrew (author)
Durrington, Paul N (author)
Doney, Alex (author)
Carr, Fiona (author)
Morris, Andrew (author)
McCarthy, Mark I (author)
Groop, LeifLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)endo-lgr (author)
Ahlqvist, EmmaLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)infl-eah (author)
Bis, Joshua C (author)
Rice, Kenneth (author)
Smith, Nicholas L (author)
Lumley, Thomas (author)
Whitsel, Eric A (author)
Stürmer, Til (author)
Boerwinkle, Eric (author)
Ngwa, Julius S (author)
O'Donnell, Christopher J (author)
Vasan, Ramachandran S (author)
Wei, Wei-Qi (author)
Wilke, Russell A (author)
Liu, Ching-Ti (author)
Sun, Fangui (author)
Guo, Xiuqing (author)
Heckbert, Susan R (author)
Post, Wendy (author)
Sotoodehnia, Nona (author)
Arnold, Alice M (author)
Stafford, Jeanette M (author)
Ding, Jingzhong (author)
Herrington, David M (author)
Kritchevsky, Stephen B (author)
Eiriksdottir, Gudny (author)
Launer, Leonore J (author)
Harris, Tamara B (author)
Chu, Audrey Y (author)
Giulianini, Franco (author)
MacFadyen, Jean G (author)
Barratt, Bryan J (author)
Nyberg, Fredrik,1961Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa, enheten för arbets-och miljömedicin,Institute of Medicine, Department of Public Health and Community Medicine, Section of Occupational and environmental medicine(Swepub:gu)xnybef (author)
Stricker, Bruno H (author)
Uitterlinden, André G (author)
Hofman, Albert (author)
Rivadeneira, Fernando (author)
Emilsson, Valur (author)
Franco, Oscar H (author)
Ridker, Paul M (author)
Gudnason, Vilmundur (author)
Liu, Yongmei (author)
Denny, Joshua C (author)
Ballantyne, Christie M (author)
Rotter, Jerome I (author)
Adrienne Cupples, L (author)
Psaty, Bruce M (author)
Palmer, Colin N A (author)
Tardif, Jean-Claude (author)
Colhoun, Helen M (author)
Hitman, Graham (author)
Krauss, Ronald M (author)
Wouter Jukema, J (author)
Caulfield, Mark J (author)
Genomik, diabetes och endokrinologiForskargrupper vid Lunds universitet (creator_code:org_t)

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In:Nature communications: Springer Science and Business Media LLC52041-1723

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By the author/editor: Postmus, Iris; Trompet, Stella; Deshmukh, Harsha ...; Barnes, Michael ...; Li, Xiaohui; Warren, Helen R; show more...; Chasman, Daniel ...; Zhou, Kaixin; Arsenault, Benoi ...; Donnelly, Louise ...; Wiggins, Kerri L; Avery, Christy L; Griffin, Paula; Feng, QiPing; Taylor, Kent D; Li, Guo; Evans, Daniel S; Smith, Albert V; de Keyser, Cathe ...; Johnson, Andrew ...; de Craen, Anton ...; Stott, David J; Buckley, Brendan ...; Ford, Ian; Westendorp, Rudi ...; Eline Slagboom, ...; Sattar, Naveed; Munroe, Patricia ...; Sever, Peter; Poulter, Neil; Stanton, Alice; Shields, Denis C; O'Brien, Eoin; Shaw-Hawkins, Su ...; Ida Chen, Y-D; Nickerson, Debor ...; Smith, Joshua D; Pierre Dubé, Mar ...; Matthijs Boekhol ...; Kees Hovingh, G; Kastelein, John ...; McKeigue, Paul M; Betteridge, John; Neil, Andrew; Durrington, Paul ...; Doney, Alex; Carr, Fiona; Morris, Andrew; McCarthy, Mark I; Groop, Leif; Ahlqvist, Emma; Bis, Joshua C; Rice, Kenneth; Smith, Nicholas ...; Lumley, Thomas; Whitsel, Eric A; Stürmer, Til; Boerwinkle, Eric; Ngwa, Julius S; O'Donnell, Chris ...; Vasan, Ramachand ...; Wei, Wei-Qi; Wilke, Russell A; Liu, Ching-Ti; Sun, Fangui; Guo, Xiuqing; Heckbert, Susan ...; Post, Wendy; Sotoodehnia, Non ...; Arnold, Alice M; Stafford, Jeanet ...; Ding, Jingzhong; Herrington, Davi ...; Kritchevsky, Ste ...; Eiriksdottir, Gu ...; Launer, Leonore ...; Harris, Tamara B; Chu, Audrey Y; Giulianini, Fran ...; MacFadyen, Jean ...; Barratt, Bryan J; Nyberg, Fredrik, ...; Stricker, Bruno ...; Uitterlinden, An ...; Hofman, Albert; Rivadeneira, Fer ...; Emilsson, Valur; Franco, Oscar H; Ridker, Paul M; Gudnason, Vilmun ...; Liu, Yongmei; Denny, Joshua C; Ballantyne, Chri ...; Rotter, Jerome I; Adrienne Cupples ...; Psaty, Bruce M; Palmer, Colin N ...; Tardif, Jean-Cla ...; Colhoun, Helen M; Hitman, Graham; Krauss, Ronald M; Wouter Jukema, J; Caulfield, Mark ...; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cardiac and Card ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Pharmacology and ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Endocrinology an ...

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