Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins.

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Fältnamn	Indikatorer	Metadata
000		07441naa a2201633 4500
001		oai:gup.ub.gu.se/207817
003		SwePub
008		240528s2014 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:lup.lub.lu.se:d95a45f6-c850-43c3-8ecc-22aceb449b61
024	7	a https://gup.ub.gu.se/publication/2078172 URI
024	7	a https://doi.org/10.1038/ncomms60682 DOI
024	7	a https://lup.lub.lu.se/record/47330122 URI
040		a (SwePub)gud (SwePub)lu
041		a eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Postmus, Iris4 aut
245	1 0	a Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins.
264		c 2014-10-28
264	1	b Springer Science and Business Media LLC,c 2014
520		a Statins effectively lower LDL cholesterol levels in large studies and the observed interindividual response variability may be partially explained by genetic variation. Here we perform a pharmacogenetic meta-analysis of genome-wide association studies (GWAS) in studies addressing the LDL cholesterol response to statins, including up to 18,596 statin-treated subjects. We validate the most promising signals in a further 22,318 statin recipients and identify two loci, SORT1/CELSR2/PSRC1 and SLCO1B1, not previously identified in GWAS. Moreover, we confirm the previously described associations with APOE and LPA. Our findings advance the understanding of the pharmacogenetic architecture of statin response.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Farmakologi och toxikologi0 (SwePub)301022 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Pharmacology and Toxicology0 (SwePub)301022 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
700	1	a Trompet, Stella4 aut
700	1	a Deshmukh, Harshal A4 aut
700	1	a Barnes, Michael R4 aut
700	1	a Li, Xiaohui4 aut
700	1	a Warren, Helen R4 aut
700	1	a Chasman, Daniel I4 aut
700	1	a Zhou, Kaixin4 aut
700	1	a Arsenault, Benoit J4 aut
700	1	a Donnelly, Louise A4 aut
700	1	a Wiggins, Kerri L4 aut
700	1	a Avery, Christy L4 aut
700	1	a Griffin, Paula4 aut
700	1	a Feng, QiPing4 aut
700	1	a Taylor, Kent D4 aut
700	1	a Li, Guo4 aut
700	1	a Evans, Daniel S4 aut
700	1	a Smith, Albert V4 aut
700	1	a de Keyser, Catherine E4 aut
700	1	a Johnson, Andrew D4 aut
700	1	a de Craen, Anton J M4 aut
700	1	a Stott, David J4 aut
700	1	a Buckley, Brendan M4 aut
700	1	a Ford, Ian4 aut
700	1	a Westendorp, Rudi G J4 aut
700	1	a Eline Slagboom, P4 aut
700	1	a Sattar, Naveed4 aut
700	1	a Munroe, Patricia B4 aut
700	1	a Sever, Peter4 aut
700	1	a Poulter, Neil4 aut
700	1	a Stanton, Alice4 aut
700	1	a Shields, Denis C4 aut
700	1	a O'Brien, Eoin4 aut
700	1	a Shaw-Hawkins, Sue4 aut
700	1	a Ida Chen, Y-D4 aut
700	1	a Nickerson, Deborah A4 aut
700	1	a Smith, Joshua D4 aut
700	1	a Pierre Dubé, Marie4 aut
700	1	a Matthijs Boekholdt, S4 aut
700	1	a Kees Hovingh, G4 aut
700	1	a Kastelein, John J P4 aut
700	1	a McKeigue, Paul M4 aut
700	1	a Betteridge, John4 aut
700	1	a Neil, Andrew4 aut
700	1	a Durrington, Paul N4 aut
700	1	a Doney, Alex4 aut
700	1	a Carr, Fiona4 aut
700	1	a Morris, Andrew4 aut
700	1	a McCarthy, Mark I4 aut
700	1	a Groop, Leifu Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)endo-lgr
700	1	a Ahlqvist, Emmau Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)infl-eah
700	1	a Bis, Joshua C4 aut
700	1	a Rice, Kenneth4 aut
700	1	a Smith, Nicholas L4 aut
700	1	a Lumley, Thomas4 aut
700	1	a Whitsel, Eric A4 aut
700	1	a Stürmer, Til4 aut
700	1	a Boerwinkle, Eric4 aut
700	1	a Ngwa, Julius S4 aut
700	1	a O'Donnell, Christopher J4 aut
700	1	a Vasan, Ramachandran S4 aut
700	1	a Wei, Wei-Qi4 aut
700	1	a Wilke, Russell A4 aut
700	1	a Liu, Ching-Ti4 aut
700	1	a Sun, Fangui4 aut
700	1	a Guo, Xiuqing4 aut
700	1	a Heckbert, Susan R4 aut
700	1	a Post, Wendy4 aut
700	1	a Sotoodehnia, Nona4 aut
700	1	a Arnold, Alice M4 aut
700	1	a Stafford, Jeanette M4 aut
700	1	a Ding, Jingzhong4 aut
700	1	a Herrington, David M4 aut
700	1	a Kritchevsky, Stephen B4 aut
700	1	a Eiriksdottir, Gudny4 aut
700	1	a Launer, Leonore J4 aut
700	1	a Harris, Tamara B4 aut
700	1	a Chu, Audrey Y4 aut
700	1	a Giulianini, Franco4 aut
700	1	a MacFadyen, Jean G4 aut
700	1	a Barratt, Bryan J4 aut
700	1	a Nyberg, Fredrik,d 1961u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa, enheten för arbets-och miljömedicin,Institute of Medicine, Department of Public Health and Community Medicine, Section of Occupational and environmental medicine4 aut0 (Swepub:gu)xnybef
700	1	a Stricker, Bruno H4 aut
700	1	a Uitterlinden, André G4 aut
700	1	a Hofman, Albert4 aut
700	1	a Rivadeneira, Fernando4 aut
700	1	a Emilsson, Valur4 aut
700	1	a Franco, Oscar H4 aut
700	1	a Ridker, Paul M4 aut
700	1	a Gudnason, Vilmundur4 aut
700	1	a Liu, Yongmei4 aut
700	1	a Denny, Joshua C4 aut
700	1	a Ballantyne, Christie M4 aut
700	1	a Rotter, Jerome I4 aut
700	1	a Adrienne Cupples, L4 aut
700	1	a Psaty, Bruce M4 aut
700	1	a Palmer, Colin N A4 aut
700	1	a Tardif, Jean-Claude4 aut
700	1	a Colhoun, Helen M4 aut
700	1	a Hitman, Graham4 aut
700	1	a Krauss, Ronald M4 aut
700	1	a Wouter Jukema, J4 aut
700	1	a Caulfield, Mark J4 aut
710	2	a Genomik, diabetes och endokrinologib Forskargrupper vid Lunds universitet4 org
773	0	t Nature communicationsd : Springer Science and Business Media LLCg 5q 5x 2041-1723
856	4	u https://www.nature.com/articles/ncomms6068.pdf
856	4	u https://portal.research.lu.se/files/3175361/7525881x primaryx freey FULLTEXT
856	4	u http://www.ncbi.nlm.nih.gov/pubmed/25350695?dopt=Abstracty FULLTEXT
856	4	u http://dx.doi.org/10.1038/ncomms6068y FULLTEXT
856	4 8	u https://gup.ub.gu.se/publication/207817
856	4 8	u https://doi.org/10.1038/ncomms6068
856	4 8	u https://lup.lub.lu.se/record/4733012

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By the author/editor: Postmus, Iris; Trompet, Stella; Deshmukh, Harsha ...; Barnes, Michael ...; Li, Xiaohui; Warren, Helen R; show more...; Chasman, Daniel ...; Zhou, Kaixin; Arsenault, Benoi ...; Donnelly, Louise ...; Wiggins, Kerri L; Avery, Christy L; Griffin, Paula; Feng, QiPing; Taylor, Kent D; Li, Guo; Evans, Daniel S; Smith, Albert V; de Keyser, Cathe ...; Johnson, Andrew ...; de Craen, Anton ...; Stott, David J; Buckley, Brendan ...; Ford, Ian; Westendorp, Rudi ...; Eline Slagboom, ...; Sattar, Naveed; Munroe, Patricia ...; Sever, Peter; Poulter, Neil; Stanton, Alice; Shields, Denis C; O'Brien, Eoin; Shaw-Hawkins, Su ...; Ida Chen, Y-D; Nickerson, Debor ...; Smith, Joshua D; Pierre Dubé, Mar ...; Matthijs Boekhol ...; Kees Hovingh, G; Kastelein, John ...; McKeigue, Paul M; Betteridge, John; Neil, Andrew; Durrington, Paul ...; Doney, Alex; Carr, Fiona; Morris, Andrew; McCarthy, Mark I; Groop, Leif; Ahlqvist, Emma; Bis, Joshua C; Rice, Kenneth; Smith, Nicholas ...; Lumley, Thomas; Whitsel, Eric A; Stürmer, Til; Boerwinkle, Eric; Ngwa, Julius S; O'Donnell, Chris ...; Vasan, Ramachand ...; Wei, Wei-Qi; Wilke, Russell A; Liu, Ching-Ti; Sun, Fangui; Guo, Xiuqing; Heckbert, Susan ...; Post, Wendy; Sotoodehnia, Non ...; Arnold, Alice M; Stafford, Jeanet ...; Ding, Jingzhong; Herrington, Davi ...; Kritchevsky, Ste ...; Eiriksdottir, Gu ...; Launer, Leonore ...; Harris, Tamara B; Chu, Audrey Y; Giulianini, Fran ...; MacFadyen, Jean ...; Barratt, Bryan J; Nyberg, Fredrik, ...; Stricker, Bruno ...; Uitterlinden, An ...; Hofman, Albert; Rivadeneira, Fer ...; Emilsson, Valur; Franco, Oscar H; Ridker, Paul M; Gudnason, Vilmun ...; Liu, Yongmei; Denny, Joshua C; Ballantyne, Chri ...; Rotter, Jerome I; Adrienne Cupples ...; Psaty, Bruce M; Palmer, Colin N ...; Tardif, Jean-Cla ...; Colhoun, Helen M; Hitman, Graham; Krauss, Ronald M; Wouter Jukema, J; Caulfield, Mark ...; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cardiac and Card ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Pharmacology and ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Endocrinology an ...

Articles in the publication: Nature communica ...

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