Search: onr:"swepub:oai:gup.ub.gu.se/208763" >
International Geogr...
-
Kristensen, S. L.
(author)
International Geographic Variation in Event Rates in Trials of Heart Failure With Preserved and Reduced Ejection Fraction
- Article/chapterEnglish2015
Publisher, publication year, extent ...
Numbers
-
LIBRIS-ID:oai:gup.ub.gu.se/208763
-
https://gup.ub.gu.se/publication/208763URI
-
https://doi.org/10.1161/CIRCULATIONAHA.114.012284DOI
Supplementary language notes
Part of subdatabase
Classification
-
Subject category:ref swepub-contenttype
-
Subject category:art swepub-publicationtype
Notes
-
BACKGROUND: -International geographic differences in outcomes may exist for clinical trials of heart failure and reduced ejection fraction (HF-REF), but there are few data for those with preserved ejection fraction (HF-PEF). METHODS AND RESULTS: -We analyzed outcomes by international geographic region in the Irbesartan in Heart Failure with Preserved systolic function trial (I-Preserve), the Candesartan in Heart failure Assessment of Reduction in Mortality and morbidity (CHARM)-Preserved trial, the CHARM-Alternative and CHARM-Added HF-REF trials, and the Controlled Rosuvastatin Multinational Trial in HF-REF (CORONA). Crude rates of heart failure hospitalization varied by geographic region, and more so for HF-PEF than for HF-REF. Rates in patients with HF-PEF were highest in the United States/Canada (HF hospitalization rate 7.6 per 100 patient-years in I-Preserve; 8.8 in CHARM-Preserved), intermediate in Western Europe (4.8/100 and 4.7/100), and lowest in Eastern Europe/Russia (3.3/100 and 2.8/100). The difference between the United States/Canada versus Eastern Europe/Russia persisted after adjustment for key prognostic variables: adjusted hazard ratios 1.34 (95% confidence interval, 1.01-1.74; P=0.04) in I-Preserve and 1.85 (95% confidence interval, 1.17-2.91; P=0.01) in CHARM-Preserved. In HF-REF, rates of HF hospitalization were slightly lower in Western Europe compared with other regions. For both HF-REF and HF-PEF, there were few regional differences in rates of all-cause or cardiovascular mortality. CONCLUSIONS: -The differences in event rates observed suggest there is international geographic variation in 1 or more of the definition and diagnosis of HF-PEF, the risk profile of patients enrolled, and the threshold for hospitalization, which has implications for the conduct of future global trials.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Kober, L.
(author)
-
Jhund, P. S.
(author)
-
Solomon, S. D.
(author)
-
Kjekshus, J. K.
(author)
-
McKelvie, R. S.
(author)
-
Zile, M. R.
(author)
-
Granger, C. B.
(author)
-
Wikstrand, John,1938Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory(Swepub:gu)xwikjo
(author)
-
Komajda, M.
(author)
-
Carson, P. E.
(author)
-
Pfeffer, M. A.
(author)
-
Swedberg, Karl,1944Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xsweka
(author)
-
Wedel, Hans
(author)
-
Yusuf, S.
(author)
-
McMurray, J. J.
(author)
-
Göteborgs universitetWallenberglaboratoriet
(creator_code:org_t)
Related titles
-
In:Circulation131, s. 43-531524-4539
Internet link
Find in a library
To the university's database
- By the author/editor
-
Kristensen, S. L ...
-
Kober, L.
-
Jhund, P. S.
-
Solomon, S. D.
-
Kjekshus, J. K.
-
McKelvie, R. S.
-
show more...
-
Zile, M. R.
-
Granger, C. B.
-
Wikstrand, John, ...
-
Komajda, M.
-
Carson, P. E.
-
Pfeffer, M. A.
-
Swedberg, Karl, ...
-
Wedel, Hans
-
Yusuf, S.
-
McMurray, J. J.
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
- Articles in the publication
-
Circulation
- By the university
-
University of Gothenburg