Complexation of aluminum with DNA.

Dyrssen, David (author): Gothenburg University,Göteborgs universitet,Institutionen för analytisk och marin kemi,Department of Analytical and Marine Chemistry,Chalmers tekniska högskola,Chalmers University of Technology,University of Gothenburg

Haraldsson, Conny (author): Gothenburg University,Göteborgs universitet,Institutionen för analytisk och marin kemi,Department of Analytical and Marine Chemistry,University of Gothenburg,Chalmers tekniska högskola,Chalmers University of Technology

Nyberg, Eva, 1958 (author): Gothenburg University,Göteborgs universitet,Institutionen för analytisk och marin kemi,Department of Analytical and Marine Chemistry,University of Gothenburg,Chalmers tekniska högskola,Chalmers University of Technology

Wedborg, Margareta, 1947 (author): Gothenburg University,Göteborgs universitet,Institutionen för analytisk och marin kemi,Department of Analytical and Marine Chemistry,University of Gothenburg,Chalmers tekniska högskola,Chalmers University of Technology

(creator_code:org_t)

1987
1987
English.
In: Journal of inorganic biochemistry. - 0162-0134 .- 1873-3344. ; 29:1, s. 67-75

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Abstract Subject headings

The extent of complexation of aluminum(III) with DNA (Calf thymus, Sigma type I) was estimated by means of two experimental techniques: potentiometric titration with a fluoride selective indicator electrode and dialysis followed by aluminum determination by graphite furnace AAS. Both types of experiments indicate that aluminum(III) is bound to DNA. The data are treated by assuming an ion exchange reaction with the phosphate diester groups. Using Rt to denote the concentration of these groups the values of log [AlMn-3R]/(Rt-3[AlMn-3R])[Al3+] decrease from approx. 7.6 to 5.6 when the concentration of sodium chloride is increased from 1 to 100 mM. In the pH range 4.5-5.5 the ion exchange constant increases approximately 0.5 log units. Dialysis gives lower values for the complex formation constant than potentiometry.

By the author/editor: Dyrssen, David; Haraldsson, Conn ...; Nyberg, Eva, 195 ...; Wedborg, Margare ...

About the subject

NATURAL SCIENCES: NATURAL SCIENCES; and Chemical Science ...; and Analytical Chemi ...

By the university: University of Gothenburg; Chalmers University of Technology

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