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Brown Adipose Tissu...
Brown Adipose Tissue Improves Whole-Body Glucose Homeostasis and Insulin Sensitivity in Humans
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Chondronikola, M. (author)
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Volpi, E. (author)
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Borsheim, E. (author)
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Porter, C. (author)
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Annamalai, P. (author)
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- Enerbäck, Sven, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk genetik och klinisk genetik,Institute of Biomedicine, Department of Medical and Clinical Genetics
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- Lidell, Martin, 1970 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk genetik och klinisk genetik,Institute of Biomedicine, Department of Medical and Clinical Genetics
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Saraf, M. K. (author)
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Labbe, S. M. (author)
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Hurren, N. M. (author)
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Yfanti, C. (author)
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Chao, T. (author)
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Andersen, C. R. (author)
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Cesani, F. (author)
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Hawkins, H. (author)
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Sidossis, L. S. (author)
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(creator_code:org_t)
- 2014-11-13
- 2014
- English.
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In: Diabetes. - : American Diabetes Association. - 0012-1797 .- 1939-327X. ; 63:12, s. 4089-4099
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https://diabetes.dia...
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https://gup.ub.gu.se...
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https://doi.org/10.2...
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Abstract
Subject headings
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- Brown adipose tissue (BAT) has attracted scientific interest as an antidiabetic tissue owing to its ability to dissipate energy as heat. Despite a plethora of data concerning the role of BAT in glucose metabolism in rodents, the role of BAT (if any) in glucose metabolism in humans remains unclear. To investigate whether BAT activation alters whole-body glucose homeostasis and insulin sensitivity in humans, we studied seven BAT-positive (BAT(+)) men and five BAT-negative (BAT(-)) men under thermoneutral conditions and after prolonged (5-8 h) cold exposure (CE). The two groups were similar in age, BMI, and adiposity. CE significantly increased resting energy expenditure, whole-body glucose disposal, plasma glucose oxidation, and insulin sensitivity in the BAT+ group only. These results demonstrate a physiologically significant role of BAT in whole-body energy expenditure, glucose homeostasis, and insulin sensitivity in humans, and support the notion that BAT may function as an antidiabetic tissue in humans.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Keyword
- TYPE-2 DIABETIC SUBJECTS
- FATTY-ACID-METABOLISM
- COLD-EXPOSURE
- ADULT
- HUMANS
- RESISTANCE
- THERMOGENESIS
- ACTIVATION
- REDUCTION
- OXIDATION
- EXERCISE
- Endocrinology & Metabolism
Publication and Content Type
- ref (subject category)
- art (subject category)
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Diabetes
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- By the author/editor
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Chondronikola, M ...
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Volpi, E.
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Borsheim, E.
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Porter, C.
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Annamalai, P.
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Enerbäck, Sven, ...
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show more...
-
Lidell, Martin, ...
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Saraf, M. K.
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Labbe, S. M.
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Hurren, N. M.
-
Yfanti, C.
-
Chao, T.
-
Andersen, C. R.
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Cesani, F.
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Hawkins, H.
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Sidossis, L. S.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
- Articles in the publication
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Diabetes
- By the university
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University of Gothenburg