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Association of vita...
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Vimaleswaran, Karani S
(author)
Association of vitamin D status with arterial blood pressure and hypertension risk: a mendelian randomisation study.
- Article/chapterEnglish2014
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LIBRIS-ID:oai:gup.ub.gu.se/210425
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https://gup.ub.gu.se/publication/210425URI
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https://doi.org/10.1016/S2213-8587(14)70113-5DOI
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https://lup.lub.lu.se/record/4523550URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-233264URI
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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Background Low plasma 25-hydroxyvitamin D (25[OH]D) concentration is associated with high arterial blood pressure and hypertension risk, but whether this association is causal is unknown. We used a mendelian randomisation approach to test whether 25(OH)D concentration is causally associated with blood pressure and hypertension risk. Methods In this mendelian randomisation study, we generated an allele score (25[OH]D synthesis score) based on variants of genes that affect 25(OH)D synthesis or substrate availability (CYP2R1 and DHCR7), which we used as a proxy for 25(OH)D concentration. We meta-analysed data for up to 108173 individuals from 35 studies in the D-CarDia collaboration to investigate associations between the allele score and blood pressure measurements. We complemented these analyses with previously published summary statistics from the International Consortium on Blood Pressure (ICBP), the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium, and the Global Blood Pressure Genetics (Global BPGen) consortium. Findings In phenotypic analyses (up to n=49363), increased 25(OH)D concentration was associated with decreased systolic blood pressure (β per 10% increase, −0·12 mm Hg, 95% CI −0·20 to −0·04; p=0·003) and reduced odds of hypertension (odds ratio [OR] 0·98, 95% CI 0·97–0·99; p=0·0003), but not with decreased diastolic blood pressure (β per 10% increase, −0·02 mm Hg, −0·08 to 0·03; p=0·37). In meta-analyses in which we combined data from D-CarDia and the ICBP (n=146581, after exclusion of overlapping studies), each 25(OH)D-increasing allele of the synthesis score was associated with a change of −0·10 mm Hg in systolic blood pressure (−0·21 to −0·0001; p=0·0498) and a change of −0·08 mm Hg in diastolic blood pressure (−0·15 to −0·02; p=0·01). When D-CarDia and consortia data for hypertension were meta-analysed together (n=142255), the synthesis score was associated with a reduced odds of hypertension (OR per allele, 0·98, 0·96–0·99; p=0·001). In instrumental variable analysis, each 10% increase in genetically instrumented 25(OH)D concentration was associated with a change of −0·29 mm Hg in diastolic blood pressure (−0·52 to −0·07; p=0·01), a change of −0·37 mm Hg in systolic blood pressure (−0·73 to 0·003; p=0·052), and an 8·1% decreased odds of hypertension (OR 0·92, 0·87–0·97; p=0·002). Interpretation Increased plasma concentrations of 25(OH)D might reduce the risk of hypertension. This finding warrants further investigation in an independent, similarly powered study.
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Cavadino, Alana
(author)
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Berry, Diane J
(author)
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Jorde, Rolf
(author)
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Dieffenbach, Aida Karina
(author)
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Lu, Chen
(author)
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Alves, Alexessander Couto
(author)
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Heerspink, Hiddo J Lambers
(author)
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Tikkanen, Emmi
(author)
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Eriksson, JoelGothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research(Swepub:gu)xerjoe
(author)
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Wong, Andrew
(author)
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Mangino, Massimo
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Jablonski, Kathleen A
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Nolte, Ilja M
(author)
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Houston, Denise K
(author)
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Ahluwalia, Tarunveer Singh
(author)
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van der Most, Peter J
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Pasko, Dorota
(author)
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Zgaga, Lina
(author)
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Thiering, Elisabeth
(author)
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Vitart, Veronique
(author)
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Fraser, Ross M
(author)
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Huffman, Jennifer E
(author)
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de Boer, Rudolf A
(author)
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Schöttker, Ben
(author)
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Saum, Kai-Uwe
(author)
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McCarthy, Mark I
(author)
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Dupuis, Josée
(author)
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Herzig, Karl-Heinz
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Sebert, Sylvain
(author)
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Pouta, Anneli
(author)
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Laitinen, Jaana
(author)
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Kleber, Marcus E
(author)
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Navis, Gerjan
(author)
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Lorentzon, Mattias,1970Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research(Swepub:gu)xlomat
(author)
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Jameson, Karen
(author)
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Arden, Nigel
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Cooper, Jackie A
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Acharya, Jayshree
(author)
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Hardy, Rebecca
(author)
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Raitakari, Olli
(author)
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Ripatti, Samuli
(author)
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Billings, Liana K
(author)
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Lahti, Jari
(author)
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Osmond, Clive
(author)
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Penninx, Brenda W
(author)
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Rejnmark, Lars
(author)
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Lohman, Kurt K
(author)
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Paternoster, Lavinia
(author)
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Stolk, Ronald P
(author)
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Hernandez, Dena G
(author)
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Byberg, LiisaUppsala universitet,Ortopedi(Swepub:uu)liisbybe
(author)
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Hagström, EmilUppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR)(Swepub:uu)emhag677
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Melhus, HåkanUppsala universitet,Uppsala kliniska forskningscentrum (UCR),Klinisk farmakogenomik och osteoporos(Swepub:uu)hakamelh
(author)
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Ingelsson, ErikUppsala universitet,Molekylär epidemiologi,Uppsala kliniska forskningscentrum (UCR),Science for Life Laboratory, SciLifeLab(Swepub:uu)ering425
(author)
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Mellström, Dan,1945Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research(Swepub:gu)xmelda
(author)
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Ljunggren, ÖstenUppsala universitet,Endokrinologi och mineralmetabolism,Uppsala kliniska forskningscentrum (UCR)(Swepub:uu)osteljun
(author)
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Tzoulaki, Ioanna
(author)
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McLachlan, Stela
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Theodoratou, Evropi
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Tiesler, Carla M T
(author)
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Jula, Antti
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Navarro, Pau
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Wright, Alan F
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Polasek, Ozren
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Wilson, James F
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Rudan, Igor
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Salomaa, Veikko
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Heinrich, Joachim
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Campbell, Harry
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Price, Jacqueline F
(author)
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Karlsson, MagnusLund University,Lunds universitet,Ortopedi - klinisk och molekylär osteoporosforskning,Forskargrupper vid Lunds universitet,Orthopedics - Clinical and Molecular Osteoporosis Research,Lund University Research Groups(Swepub:lu)orto-mka
(author)
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Lind, LarsUppsala universitet,Kardiovaskulär epidemiologi,Uppsala kliniska forskningscentrum (UCR)(Swepub:uu)larslind
(author)
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Michaëlsson, KarlUppsala universitet,Ortopedi(Swepub:uu)karlmich
(author)
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Bandinelli, Stefania
(author)
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Frayling, Timothy M
(author)
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Hartman, Catharina A
(author)
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Sørensen, Thorkild I A
(author)
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Kritchevsky, Stephen B
(author)
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Langdahl, Bente Lomholt
(author)
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Eriksson, Johan G
(author)
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Florez, Jose C
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Spector, Tim D
(author)
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Lehtimäki, Terho
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Kuh, Diana
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Humphries, Steve E
(author)
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Cooper, Cyrus
(author)
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Ohlsson, Claes,1965Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research(Swepub:gu)xohlcl
(author)
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März, Winfried
(author)
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de Borst, Martin H
(author)
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Kumari, Meena
(author)
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Kivimaki, Mika
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Wang, Thomas J
(author)
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Power, Chris
(author)
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Brenner, Hermann
(author)
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Grimnes, Guri
(author)
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van der Harst, Pim
(author)
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Snieder, Harold
(author)
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Hingorani, Aroon D
(author)
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Pilz, Stefan
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Whittaker, John C
(author)
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Järvelin, Marjo-Riitta
(author)
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Hyppönen, Elina
(author)
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Göteborgs universitetCentre for Bone and Arthritis Research
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In:The lancet. Diabetes & endocrinology2:9, s. 719-292213-85952213-8587
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