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Premature thymic in...
Premature thymic involution is independent of structural plasticity of the thymic stroma.
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Franckaert, Dean (author)
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Schlenner, Susan M (author)
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Heirman, Nathalie (author)
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Gill, Jason (author)
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- Skogberg, Gabriel (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research
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- Ekwall, Olov, 1968 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research
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Put, Karen (author)
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Linterman, Michelle A (author)
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Dooley, James (author)
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Liston, Adrian (author)
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(creator_code:org_t)
- 2015-02-23
- 2015
- English.
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In: European journal of immunology. - : Wiley. - 1521-4141 .- 0014-2980. ; 45:5, s. 1535-1547
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Abstract
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- The thymus is the organ devoted to T-cell production. The thymus undergoes multiple rounds of atrophy and redevelopment before degenerating with age in a process known as involution. This process is poorly understood, despite the influence the phenomenon has on peripheral T-cell numbers. Here we have investigated the FVB/N mouse strain, which displays premature thymic involution. We find multiple architectural and cellular features that precede thymic involution, including disruption of the epithelial-endothelial relationship and a progressive loss of pro-T cells. The architectural features, reminiscent of the human thymus, are intrinsic to the non-hematopoietic compartment and are neither necessary nor sufficient for thymic involution. By contrast, the loss of pro-T cells is intrinsic to the hematopoietic compartment, and is sufficient to drive premature involution. These results identify pro-T-cell loss as the main driver of premature thymic involution, and highlight the plasticity of the thymic stroma, capable of maintaining function across diverse inter-strain architectures. This article is protected by copyright. All rights reserved.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Keyword
- FVB/N mouse;Involution;Pro-T cells;Thymic epithelium cells;Thymus;Vascularization
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Franckaert, Dean
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Schlenner, Susan ...
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Heirman, Nathali ...
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Gill, Jason
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Skogberg, Gabrie ...
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Ekwall, Olov, 19 ...
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show more...
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Put, Karen
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Linterman, Miche ...
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Dooley, James
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Liston, Adrian
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Pediatrics
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Immunology in th ...
- Articles in the publication
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European journal ...
- By the university
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University of Gothenburg