Search: onr:"swepub:oai:gup.ub.gu.se/212729" >
Ex vivo alendronate...
Ex vivo alendronate localization at the mesoporous titania implant/bone interface
-
- Karlsson, Johan, 1984 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
-
- Harmankaya, Necati, 1983 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för biomaterialvetenskap,Institute of Clinical Sciences, Department of Biomaterials,University of Gothenburg
-
- Allard, Stefan, 1968 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
-
show more...
-
- Palmquist, Anders, 1977 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för biomaterialvetenskap,Institute of Clinical Sciences, Department of Biomaterials,University of Gothenburg
-
- Halvarsson, Mats, 1965 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
-
- Tengvall, Pentti (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för biomaterialvetenskap,Institute of Clinical Sciences, Department of Biomaterials,University of Gothenburg
-
- Andersson, Martin, 1974 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
-
show less...
-
(creator_code:org_t)
- 2015-01-11
- 2015
- English.
-
In: Journal of materials science. Materials in medicine. - : Springer Science and Business Media LLC. - 1573-4838 .- 0957-4530. ; 26
- Related links:
-
http://dx.doi.org/10...
-
show more...
-
https://gup.ub.gu.se...
-
https://doi.org/10.1...
-
https://research.cha...
-
https://urn.kb.se/re...
-
show less...
Abstract
Subject headings
Close
- An attractive approach in implant technology is local drug delivery, and design of efficient, safe and reliable treatments. Ourhitherto strategy has been to coat Ti implants with a thin mesoporous TiO2 film that in turnis loaded with an osteoporosis drug, such as Alendronate (ALN) that is known to suppress osteoclastic activity. This system has proven highly successful and results in excellent osseointegration. However, more detailed information about drug-release and distribution at the bone/implant interface is needed. In this study, (14)C-ALN loaded titanium implants were placed up to 8weeks into rat tibia and the spatial-temporal distribution of the drug was evaluated. Autoradiography data demonstrated a sustained release of (14)C-ALN and the releaseddrug remained bound to bone in close vicinity, within 500 micrometers,of the implants. Liquid scintillation counting experiments confirmed that the distal transport of released (14)C-ALN was extremely low. The results are favorable as they show that ALN stays for a long time in the vicinity of the implant and may therefore improve for a long time the mechanical fixation of bone anchored implants. Moreover, these findings suggest due to the low systemic spreading a minimal risk of Alendronate related systemic side effects.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Odontologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dentistry (hsv//eng)
Keyword
- bisphosphonate
- alendronate
- implant
- titanium
- drug delivery
- titanium
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database