Search: onr:"swepub:oai:gup.ub.gu.se/212894" >
Cyclic AMP in oocyt...
Cyclic AMP in oocytes controls meiotic prophase I and primordial folliculogenesis in the perinatal mouse ovary
-
Wang, Y. J. (author)
-
Teng, Z. (author)
-
Li, G. (author)
-
show more...
-
Mu, X. Y. (author)
-
Wang, Z. P. (author)
-
Feng, L. Z. (author)
-
Niu, W. B. (author)
-
Huang, K. (author)
-
Xiang, X. (author)
-
Wang, C. (author)
-
- Zhang, Hua (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology
-
Xia, G. L. (author)
-
show less...
-
(creator_code:org_t)
- The Company of Biologists, 2015
- 2015
- English.
-
In: Development. - : The Company of Biologists. - 0950-1991 .- 1477-9129. ; 142:2, s. 343-351
- Related links:
-
https://dev.biologis...
-
show more...
-
https://gup.ub.gu.se...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- In mammalian ovaries, a fixed population of primordial follicles forms during the perinatal stage and the oocytes contained within are arrested at the dictyate stage of meiotic prophase I. In the current study, we provide evidence that the level of cyclic AMP ( cAMP) in oocytes regulates oocyte meiotic prophase I and primordial folliculogenesis in the perinatal mouse ovary. Our results show that the early meiotic development of oocytes is closely correlated with increased levels of intra-oocyte cAMP. Inhibiting cAMP synthesis in fetal ovaries delayed oocyte meiotic progression and inhibited the disassembly and degradation of synaptonemal complex protein 1. In addition, inhibiting cAMP synthesis in in vitro cultured fetal ovaries prevented primordial follicle formation. Finally, using an in situ oocyte chromosome analysis approach, we found that the dictyate arrest of oocytes is essential for primordial follicle formation under physiological conditions. Taken together, these results suggest a role for cAMP in early meiotic development and primordial follicle formation in the mouse ovary.
Subject headings
- NATURVETENSKAP -- Biologi -- Utvecklingsbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Developmental Biology (hsv//eng)
Keyword
- cAMP
- Meiotic prophase I
- Oocytes
- Primordial follicle formation
- MAMMALIAN SYNAPTONEMAL COMPLEX
- NERVE GROWTH-FACTOR
- GERM-CELL FATE
- FOLLICLE FORMATION
- RETINOIC ACID
- MEIOSIS
- FETAL
- MICE
- RAT
- SPERMATOCYTES
- Developmental Biology
- LANI PE
- 1991
- HUMAN GENETICS
- V88
- P64
- FELICI M
- 1993
- DEVELOPMENTAL BIOLOGY
- V157
- P277
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Wang, Y. J.
-
Teng, Z.
-
Li, G.
-
Mu, X. Y.
-
Wang, Z. P.
-
Feng, L. Z.
-
show more...
-
Niu, W. B.
-
Huang, K.
-
Xiang, X.
-
Wang, C.
-
Zhang, Hua
-
Xia, G. L.
-
show less...
- About the subject
-
- NATURAL SCIENCES
-
NATURAL SCIENCES
-
and Biological Scien ...
-
and Developmental Bi ...
- Articles in the publication
-
Development
- By the university
-
University of Gothenburg