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Inhibition of cyclo...
Inhibition of cyclooxygenase-2 prevents chronic and recurrent cystitis
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Hannan, T. J. (author)
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Roberts, P. L. (author)
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Riehl, T. E. (author)
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- van der Post, Sjoerd, 1981 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology
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Binkley, J. M. (author)
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Schwartz, D. J. (author)
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Miyoshi, H. (author)
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Mack, M. (author)
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Schwendener, R. A. (author)
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Hooton, T. M. (author)
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Stappenbeck, T. S. (author)
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- Hansson, Gunnar C., 1951 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology
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Stenson, W. F. (author)
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Colonna, M. (author)
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Stapleton, A. E. (author)
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Hultgren, S. J. (author)
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(creator_code:org_t)
- Elsevier, 2014
- 2014
- English.
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In: EBioMedicine. - : Elsevier. - 2352-3964. ; 1:1, s. 46-57
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https://gup.ub.gu.se...
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Abstract
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- The spread of multidrug-resistant microorganisms globally has created an urgent need for novel therapeuticstrategies to combat urinary tract infections (UTIs). Immunomodulatory therapy may provide benefit, as treatmentof mice with dexamethasone during acute UTI improved outcome by reducing the development of chroniccystitis, which predisposes to recurrent infection. Herewe discovered soluble biomarkers engaged inmyeloid celldevelopment and chemotaxis that were predictive of future UTI recurrence when elevated in the sera of youngwomen with UTI. Translation of these findings revealed that temperance of the neutrophil response early duringUTI, and specifically disruption of bladder epithelial transmigration of neutrophils by inhibition ofcyclooxygenase-2, protected mice against chronic and recurrent cystitis. Further, proteomics identified bladderepithelial remodeling consequent to chronic infection that enhances sensitivity to neutrophil damage. Thus, cyclooxygenase-2 expression during acute UTI is a critical molecular trigger determining disease outcome anddrugs targeting cyclooxygenase-2 could prevent recurrent UTI.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Keyword
- Chronic infection
- COX-2
- Immunomodulatory therapy
- Immunopathology
- Mucosal immunology
- Recurrent infection
- UPEC
- Urinary tract infection UTI
- Uropathogenic E. coli
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Hannan, T. J.
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Roberts, P. L.
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Riehl, T. E.
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van der Post, Sj ...
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Binkley, J. M.
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Schwartz, D. J.
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show more...
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Miyoshi, H.
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Mack, M.
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Schwendener, R. ...
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Hooton, T. M.
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Stappenbeck, T. ...
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Hansson, Gunnar ...
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Stenson, W. F.
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Colonna, M.
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Stapleton, A. E.
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Hultgren, S. J.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
- Articles in the publication
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EBioMedicine
- By the university
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University of Gothenburg