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Efficient predictio...
Efficient prediction of human protein-protein interactions at a global scale
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- Schoenrock, A. (author)
- Carleton University, Ottawa, Canada
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- Samanfar, B. (author)
- Carleton University, Ottawa, Canada
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- Pitre, S. (author)
- Carleton University, Ottawa, Canada
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- Hooshyar, M. (author)
- Carleton University, Ottawa, Canada
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- Jin, K. (author)
- University of Toronto, Toronto, Canada
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- Phillips, C. A. (author)
- University of Tennessee, Knoxville, Tennessee, USA
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- Wang, Hui (author)
- Linköpings universitet,Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics,Avdelningen för kliniska vetenskaper,Hälsouniversitetet,Gothenburg University, Gothenburg, Sweden,The Centre for Individualized Medication
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- Phanse, S. (author)
- University of Toronto, Toronto, Canada
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- Omidi, K. (author)
- University of Toronto, Toronto, Canada
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- Gui, Y. (author)
- University of Toronto, Toronto, Canada
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- Alamgir, M. (author)
- University of Toronto, Toronto, Canada,Carleton University, Ottawa, Canada
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- Wong, A. (author)
- University of Toronto, Toronto, Canada
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- Barrenäs, Fredrik, 1981 (author)
- Linköpings universitet,Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics,Avdelningen för kliniska vetenskaper,Hälsouniversitetet,Gothenburg University, Gothenburg, Sweden,The Centre for Individualized Medication
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- Babu, M. (author)
- University of Regina, Regina, Saskatchewan, Canada
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- Benson, Mikael, 1954 (author)
- Östergötlands Läns Landsting,Linköpings universitet,Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics,Avdelningen för kliniska vetenskaper,Hälsouniversitetet,Allergicentrum US,Barn- och ungdomskliniken i Linköping,Gothenburg University, Gothenburg, Sweden,The Centre for Individualized Medication
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Langston, M. A. (author)
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- Green, J. R. (author)
- Carleton University, Ottawa, Canada
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- Dehne, F. (author)
- Carleton University, Ottawa, Canada
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- Golshani, A. (author)
- Carleton University, Ottawa, Canada
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(creator_code:org_t)
- 2014-12-10
- 2014
- English.
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In: Bmc Bioinformatics. - : Springer Science and Business Media LLC. - 1471-2105. ; 15
- Related links:
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https://bmcbioinform...
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https://liu.diva-por... (primary) (Raw object)
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Subject headings
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- Background: Our knowledge of global protein-protein interaction (PPI) networks in complex organisms such as humans is hindered by technical limitations of current methods. Results: On the basis of short co-occurring polypeptide regions, we developed a tool called MP-PIPE capable of predicting a global human PPI network within 3 months. With a recall of 23% at a precision of 82.1%, we predicted 172,132 putative PPIs. We demonstrate the usefulness of these predictions through a range of experiments. Conclusions: The speed and accuracy associated with MP-PIPE can make this a potential tool to study individual human PPI networks (from genomic sequences alone) for personalized medicine.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Keyword
- Protein-protein interactions
- Computational prediction
- Human proteome
- Massively parallel
- YEAST SACCHAROMYCES-CEREVISIAE
- SHORT POLYPEPTIDE SEQUENCES
- INTERACTION
- NETWORKS
- ALLERGIC RHINITIS
- DNA-DAMAGE
- COMPUTATIONAL METHODS
- MESSENGER-RNA
- BREAST-CANCER
- AURORA B
- DISEASE
- Biochemical Research Methods
- Biotechnology & Applied Microbiology
- Mathematical & Computational Biology
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Schoenrock, A.
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Samanfar, B.
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Pitre, S.
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Hooshyar, M.
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Jin, K.
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Phillips, C. A.
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show more...
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Wang, Hui
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Phanse, S.
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Omidi, K.
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Gui, Y.
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Alamgir, M.
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Wong, A.
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Barrenäs, Fredri ...
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Babu, M.
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Benson, Mikael, ...
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Langston, M. A.
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Green, J. R.
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Dehne, F.
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Golshani, A.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
- Articles in the publication
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Bmc Bioinformati ...
- By the university
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University of Gothenburg
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Linköping University