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Prophylaxis and tre...
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Navér, LarsKarolinska Institutet
(author)
Prophylaxis and treatment of HIV-1 infection in pregnancy: Swedish recommendations 2013.
- Article/chapterEnglish2014
Publisher, publication year, extent ...
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2014-04-22
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Informa UK Limited,2014
Numbers
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LIBRIS-ID:oai:gup.ub.gu.se/213338
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https://gup.ub.gu.se/publication/213338URI
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https://doi.org/10.3109/00365548.2014.898333DOI
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https://lup.lub.lu.se/record/4559043URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:129073928URI
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Prophylaxis and treatment with antiretroviral drugs and elective caesarean section delivery have resulted in very low mother-to-child transmission of HIV during recent years. Updated general treatment guidelines and increasing knowledge about mother-to-child transmission have necessitated regular revisions of the recommendations for the prophylaxis and treatment of HIV-1 infection in pregnancy. The Swedish Reference Group for Antiviral Therapy (RAV) updated the recommendations from 2010 at an expert meeting on 11 September 2013. The most important revisions are the following: (1) ongoing efficient treatment at confirmed pregnancy may, with a few exceptions, be continued; (2) if treatment is initiated during pregnancy, the recommended first-line therapy is essentially the same as for non-pregnant women; (3) raltegravir may be added to achieve rapid reduction in HIV RNA; (4) vaginal delivery is recommended if at > 34 gestational weeks and HIV RNA is < 50 copies/ml and no obstetric contraindications exist; (5) if HIV RNA is < 50 copies/ml and delivery is at > 34 gestational weeks, intravenous zidovudine is not recommended regardless of the delivery mode; (6) if HIV RNA is > 50 copies/ml close to delivery, it is recommended that the mother should undergo a planned caesarean section, intravenous zidovudine, and oral nevirapine, and the infant should receive single-dose nevirapine at 48-72 h of age and post-exposure prophylaxis with 2 drugs; (7) if delivery is preterm at < 34 gestational weeks, a caesarean section delivery should if possible be performed, with intravenous zidovudine and oral nevirapine given to the mother, and single-dose nevirapine given to the infant at 48-72 h of age, as well as post-exposure prophylaxis with 2 additional drugs.
Subject headings and genre
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Albert, JanKarolinska Institutet
(author)
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Böttiger, YlvaKarolinska Institutet
(author)
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Carlander, ChristinaKarolinska Institutet
(author)
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Flamholc, LeoLund University,Lunds universitet,Enheten för infektionssjukdomar,Forskargrupper vid Lunds universitet,Infectious Diseases Research Unit,Lund University Research Groups(Swepub:lu)inf-lfl
(author)
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Gisslén, Magnus,1962Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine(Swepub:gu)xgissm
(author)
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Josephson, Filip
(author)
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Karlström, Olof
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Lindborg, Lena
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Svedhem-Johansson, VeronicaKarolinska Institutet
(author)
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Svennerholm, Bo
(author)
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Sönnerborg, AndersKarolinska Institutet
(author)
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Yilmaz, Aylin,1974Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine(Swepub:gu)xyilay
(author)
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Pettersson, KarinKarolinska Institutet
(author)
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Karolinska InstitutetEnheten för infektionssjukdomar
(creator_code:org_t)
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In:Scandinavian journal of infectious diseases: Informa UK Limited46:6, s. 401-111651-19800036-5548
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Navér, Lars
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Albert, Jan
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Josephson, Filip
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Karlström, Olof
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Lindborg, Lena
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Svedhem-Johansso ...
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Yilmaz, Aylin, 1 ...
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University of Gothenburg
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Karolinska Institutet