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Vectorcardiography ...
Vectorcardiography for Optimization of Stimulation Intervals in Cardiac Resynchronization Therapy.
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van Deursen, Caroline J M (author)
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- Wecke, Liliane (author)
- Karolinska Institutet
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van Everdingen, Wouter M (author)
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- Ståhlberg, Marcus (author)
- Karolinska Institutet
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Janssen, Michel H G (author)
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- Braunschweig, Frieder (author)
- Karolinska Institutet
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- Bergfeldt, Lennart, 1950 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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Crijns, Harry J G M (author)
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Vernooy, Kevin (author)
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Prinzen, Frits W (author)
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(creator_code:org_t)
- 2015-03-06
- 2015
- English.
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In: Journal of cardiovascular translational research. - : Springer Science and Business Media LLC. - 1937-5395 .- 1937-5387. ; 8:2, s. 128-137
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Abstract
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- Current optimization of atrioventricular (AV) and interventricular (VV) intervals in cardiac resynchronization therapy (CRT) is time consuming and subject to noise. We aimed to prove the principle that the best hemodynamic effect of CRT is achieved by cancelation of opposing electrical forces, detectable from the QRS morphology in the 3D vectorcardiogram (VCG). Different degrees of left (LV) and right ventricular (RV) pre-excitation were induced, using variation in AV intervals during LV pacing in 20 patients with left bundle branch block (LBBB) and variation in VV intervals during biventricular pacing in 18 patients with complete AV block or atrial fibrillation. The smallest QRS vector area identified stimulation intervals with minimal systolic stretch (median difference [IQR] 20ms [-20, 20ms] and maximal hemodynamic response (10ms [-20, 40ms]). Reliability of VCG measurements was superior to hemodynamic measurements. This study proves the principle that VCG analysis may allow easy and reliable optimization of stimulation intervals in CRT patients.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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van Deursen, Car ...
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Wecke, Liliane
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van Everdingen, ...
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Ståhlberg, Marcu ...
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Janssen, Michel ...
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Braunschweig, Fr ...
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show more...
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Bergfeldt, Lenna ...
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Crijns, Harry J ...
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Vernooy, Kevin
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Prinzen, Frits W
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
- Articles in the publication
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Journal of cardi ...
- By the university
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University of Gothenburg
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Karolinska Institutet