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- Nieuwdorp, MaxGothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory (author)
Role of the microbiome in energy regulation and metabolism
- Article/chapterEnglish2014
Publisher, publication year, extent ...
- W.B. Saunders,2014
Numbers
- LIBRIS-ID:oai:gup.ub.gu.se/214731
- https://gup.ub.gu.se/publication/214731URI
- https://doi.org/10.1053/j.gastro.2014.02.008DOI
Supplementary language notes
- Language:English
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- SwePubSwePub
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Notes
- Intestinal microbes regulate metabolic function and energy balance; an altered microbial ecology is believed to contribute to the development of several metabolic diseases. Relative species abundance and metabolic characteristics of the intestinal microbiota change substantially in those who are obese or have other metabolic disorders and in response to ingested nutrients or therapeutic agents. The mechanisms through which the intestinal microbiota and its metabolites affect host homeostasis are just beginning to be understood. We review the relationships between the intestinal microbiota and host metabolism, including energy intake, use, and expenditure, in relation to glucose and lipid metabolism. These associations, along with interactions among the intestinal microbiota, mucus layer, bile acids, and mucosal immune responses, reveal potential mechanisms by which the microbiota affect metabolism. We discuss how controlled studies involving direct perturbations of microbial communities in human and animal models are required to identify effective therapeutic targets in the microbiota. © 2014 by the AGA Institute.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Gastroenterologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Gastroenterology and Hepatology hsv//eng
- Bile Acids
- Energy Expenditure
- Gut Microbiota
- Obesity
- bile acid
- article
- commensal
- diabetes mellitus
- endotoxemia
- energy
- energy balance
- homeostasis
- human
- immune response
- insulin resistance
- insulin sensitivity
- intestine flora
- lipid metabolism
- metabolism
- microbial community
- microbial diversity
- mucus
- nonhuman
- physiological process
- population abundance
- priority journal
- regulatory mechanism
- Animals
- Bacteria
- Bile Acids and Salts
- Energy Metabolism
- Gastrointestinal Diseases
- Host-Pathogen Interactions
- Humans
- Intestines
- Microbiota
- Probiotics
Added entries (persons, corporate bodies, meetings, titles ...)
- Gilijamse, P. W. (author)
- Pai, N. (author)
- Kaplan, L. M. (author)
- Göteborgs universitetWallenberglaboratoriet (creator_code:org_t)
Related titles
- In:Gastroenterology: W.B. Saunders146:6, s. 1525-15330016-50851528-0012
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- Nieuwdorp, Max
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- Gastroenterology
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- University of Gothenburg
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