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Conformational acti...
Conformational activation of visual rhodopsin in native disc membranes
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- Malmerberg, Erik, 1980 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology
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Bovee-Geurts, P. H. M. (author)
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- Katona, Gergely, 1975 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology
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Deupi, X. (author)
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- Arnlund, David (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology
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- Wickstrand, Cecilia (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology
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- Johansson, Linda C, 1983 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology
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- Westenhoff, Sebastian, 1978 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology
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- Nazarenko, Elena, 1980 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology
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Schertler, G. F. X. (author)
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Menzel, A. (author)
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de Grip, W. J. (author)
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- Neutze, Richard, 1969 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology
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(creator_code:org_t)
- American Association for the Advancement of Science (AAAS), 2015
- 2015
- English.
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In: Science Signaling. - : American Association for the Advancement of Science (AAAS). - 1945-0877 .- 1937-9145. ; 8:367
- Related links:
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https://doi.org/10.1...
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Abstract
Subject headings
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- Rhodopsin is the G protein-coupled receptor (GPCR) that serves as a dim-light receptor for vision in vertebrates. We probed light-induced conformational changes in rhodopsin in its native membrane environment at room temperature using time-resolved wide-angle x-ray scattering. We observed a rapid conformational transition that is consistent with an outward tilt of the cytoplasmic portion of transmembrane helix 6 concomitant with an inward movement of the cytoplasmic portion of transmembrane helix 5. These movements were considerably larger than those reported from the basis of crystal structures of activated rhodopsin, implying that light activation of rhodopsin involves a more extended conformational change than was previously suggested.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Keyword
- PROTEIN-COUPLED RECEPTOR
- X-RAY-SCATTERING
- PHOTOACTIVE YELLOW PROTEIN
- TIME-RESOLVED WAXS
- CRYSTAL-STRUCTURE
- STRUCTURAL DYNAMICS
- FLUORESCENCE
- SPECTROSCOPY
- METARHODOPSIN-II
- BOVINE RHODOPSIN
- BINDING-SITE
- Biochemistry & Molecular Biology
- Cell Biology
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Malmerberg, Erik ...
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Bovee-Geurts, P. ...
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Katona, Gergely, ...
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Deupi, X.
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Arnlund, David
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Wickstrand, Ceci ...
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show more...
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Johansson, Linda ...
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Westenhoff, Seba ...
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Nazarenko, Elena ...
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Schertler, G. F. ...
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Menzel, A.
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de Grip, W. J.
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Neutze, Richard, ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
- Articles in the publication
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Science Signalin ...
- By the university
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University of Gothenburg