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The risk for diabet...
The risk for diabetic nephropathy is low in young adults in a 17-year follow-up from the Diabetes Incidence Study in Sweden (DISS). Older age and higher BMI at diabetes onset can be important risk factors
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- Svensson, M.K, 1965 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine,University of Gothenburg, Sweden
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- Tyrberg, Maria (author)
- Lund University,Lunds universitet,Kliniska Vetenskaper, Helsingborg,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Clinical Sciences, Helsingborg,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University, Sweden
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- Nystrom, L. (author)
- Umeå University, Sweden
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- Arnqvist, Hans (author)
- Linköpings universitet,Avdelningen för cellbiologi,Hälsouniversitetet,Region Östergötland, Endokrinmedicinska kliniken
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- Bolinder, J. (author)
- Karolinska Institutet
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- Ostman, J. (author)
- Karolinska Institute, Sweden
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- Gudbjörnsdottir, Soffia, 1962 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine,University of Gothenburg, Sweden
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- Landin-Olsson, Mona (author)
- Lund University,Lunds universitet,Medicin, Lund,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medicine, Lund,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University, Sweden
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- Eriksson, Jan W. (author)
- Uppsala universitet,Klinisk diabetologi och metabolism,Uppsala University, Sweden
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(creator_code:org_t)
- 2014-09-03
- 2015
- English.
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In: Diabetes-Metabolism Research and Reviews. - : Wiley. - 1520-7560 .- 1520-7552. ; 31:2, s. 138-146
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Abstract
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- AimsThe main objective of this study was to estimate the occurrence of diabetic nephropathy in a population-based cohort of patients diagnosed with diabetes as young adults (15-34years). MethodsAll 794 patients registered 1987-1988 in the Diabetes Incidence Study in Sweden (DISS) were invited to a follow-up study 15-19years after diagnosis, and 468 (58%) participated. Analysis of islet antibodies was used to classify type of diabetes. ResultsAfter median 17years of diabetes, 15% of all patients, 14% T1DM and 25% T2DM, were diagnosed with diabetic nephropathy. Ninety-one percent had microalbuminuria and 8.6% macroalbuminuria. Older age at diagnosis (HR 1.05; 95% CI 1.01-1.10 per year) was an independent and a higher BMI at diabetes diagnosis (HR 1.04; 95% CI 1.00-1.09 per 1kg/m(2)), a near-significant predictor of development of diabetic nephropathy. Age at onset of diabetes (p=0.041), BMI (p=0.012) and HbA1c (p<0.001) were significant predictors of developing diabetic nephropathy between 9 and 17years of diabetes. At 17years of diabetes duration, a high HbA1c level (OR 1.06; 95% CI 1.03-1.08 per 1mmol/mol increase) and systolic blood pressure (OR 1.08; 95% CI 1.051.12 per 1mmHg increase) were associated with DN. ConclusionsPatients with T2DM diagnosed as young adults seem to have an increased risk to develop diabetic nephropathy compared with those with T1DM. Older age and higher BMI at diagnosis of diabetes were risk markers for development of diabetic nephropathy. In addition, poor glycaemic control but not systolic blood pressure at 9years of follow-up was a risk marker for later development of diabetic nephropathy. Copyright (c) 2014 John Wiley & Sons, Ltd.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Keyword
- diabetic nephropathy
- hyperglycaemia
- blood pressure
- type 1 diabetes mellitus
- type 2 diabetes mellitus
- islet antibodies
- STAGE RENAL-DISEASE
- BETA-CELL FUNCTION
- INSULIN-SECRETION
- GLYCEMIC
- CONTROL
- TYPE-1
- RETINOPATHY
- MELLITUS
- MICROALBUMINURIA
- DIAGNOSIS
- YOUTH
- Endocrinology & Metabolism
- type 1 diabetes
- mellitus
- diabetic nephropathy; hyperglycaemia; blood pressure; type 1 diabetes mellitus; type 2 diabetes mellitus; islet antibodies
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Svensson, M.K, 1 ...
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Tyrberg, Maria
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Nystrom, L.
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Arnqvist, Hans
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Bolinder, J.
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Ostman, J.
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show more...
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Gudbjörnsdottir, ...
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Landin-Olsson, M ...
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Eriksson, Jan W.
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
- Articles in the publication
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Diabetes-Metabol ...
- By the university
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University of Gothenburg
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Lund University
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Uppsala University
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Linköping University
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Karolinska Institutet