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Association between...
Association between low C-peptide and low lumbar bone mineral density in postmenopausal women without diabetes
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Montalcini, T. (author)
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Gallotti, P. (author)
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Coppola, A. (author)
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Zambianchi, V. (author)
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Fodaro, M. (author)
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Galliera, E. (author)
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Marazzi, M. G. (author)
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- Romeo, Stefano, 1976 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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Giannini, S. (author)
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Romanelli, M. M. C. (author)
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Pujia, A. (author)
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Gazzaruso, C. (author)
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(creator_code:org_t)
- 2015-01-24
- 2015
- English.
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In: Osteoporosis International. - : Springer Science and Business Media LLC. - 0937-941X .- 1433-2965. ; 26:5, s. 1639-1646
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
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- In this population-based, cross-sectional study in Italian postmenopausal females not affected by diabetes, we showed a link between serum C-peptide and lumbar bone mineral density, suggesting that C-peptide exerts an insulin-independent effect on bone mass. Introduction It is well known that type 1 (T1) diabetes, characterized by insulin and C-peptide deficiency, is associated with a low lumbar bone mineral density and an increased risk for fracture. While a role for insulin in the pathogenesis of osteoporosis has been demonstrated, the association between C-peptide and the bone mineral density has not been investigated. We conducted a study in a cohort of 84 postmenopausal women without diabetes to clarify the association between serum C-peptide and the lumbar bone mineral density. Methods Participants underwent a bone mineral density evaluation by DXA and biochemical analysis including the C-peptide assay. rteen percent of the population had osteoporosis and 38 % had osteopenia. With ANOVA test, we showed that women with the lowest C-peptide concentration had lower lumbar mineral density in comparison to those in all other C-peptide concentration group (p = 0.02 among groups after adjustment). The univariate and multivariate analysis showed that C-peptide was positively associated with both lumbar T-score and Z-score besides other well-known factors like age (with T-score p < 0.001; beta = -0.38) and BMI (with T-score p = 0.009; beta = 0.34), while insulin was not correlated with the lumbar bone mineral density. The area under the receiver operating characteristic (ROC) curve for C-peptide to predict the absence of lumbar osteoporosis was 0.74 (SE = 0.073; p = 0.013). Conclusions These results suggest that C-peptide may exert an insulin- and BMI-independent effect on lumbar bone mineral density and that further large-scale studies are needed in order to clarify its role in bone mineralization especially in subjects without diabetes.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Keyword
- C-peptide
- Lumbar bone mineral density
- Menopause
- Survey
- FRACTURE RISK
- MELLITUS
- INSULIN
- OSTEOPOROSIS
- ADOLESCENTS
- TYPE-1
- METABOLISM
- RESORPTION
- CHILDREN
- LIFE
- Endocrinology & Metabolism
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Montalcini, T.
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Gallotti, P.
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Coppola, A.
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Zambianchi, V.
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Fodaro, M.
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Galliera, E.
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show more...
-
Marazzi, M. G.
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Romeo, Stefano, ...
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Giannini, S.
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Romanelli, M. M. ...
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Pujia, A.
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Gazzaruso, C.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
- Articles in the publication
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Osteoporosis Int ...
- By the university
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University of Gothenburg