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Altered cytokine le...
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Jernås, Margareta,1961Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
(author)
Altered cytokine levels in pediatric ITP.
- Article/chapterEnglish2015
Publisher, publication year, extent ...
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2015-03-25
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Informa UK Limited,2015
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LIBRIS-ID:oai:gup.ub.gu.se/217441
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https://gup.ub.gu.se/publication/217441URI
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https://doi.org/10.3109/09537104.2014.974526DOI
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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Immune thrombocytopenia (ITP) is an autoimmune disease where platelets are destroyed prematurely. In the majority of children, the disease resolves, but in some, it becomes chronic. Cytokines are important mediators of the immune response and are known to be dysregulated in autoimmune diseases. Therefore, our aim was to investigate differences in plasma levels of cytokines between children with ITP and healthy controls. We had two cohorts of children: one Swedish with 18 children with ITP and seven healthy children and a second Chinese one with 58 children with ITP and 30 healthy children. Plasma levels of chemokine (C-X3-C motif) ligand 1 (CX3CL1), transforming growth factor β1 (TGF-β1), and interleukin 22 (IL-22) were analyzed in both cohorts using enzyme-linked immunosorbent assays (ELISAs). We found lower plasma levels of TGF-β1 and elevated levels of CX3CL1 and IL-22 in children with ITP compared with controls in both the Swedish and the Chinese cohort. In conclusion, all three cytokines differ between pediatric ITP and healthy controls and may, therefore, be potential biomarkers for the disease.
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Hou, Yu
(author)
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Strömberg Celind, Frida,1980
(author)
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Shao, Linlin
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Wang, Qian
(author)
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Ju, Xiuli
(author)
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Mellgren, Karin,1962
(author)
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Wadenvik, Hans,1955Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition(Swepub:gu)xwadha
(author)
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Hou, Ming
(author)
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Olsson, Bob,1969Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xolsbo
(author)
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Göteborgs universitetInstitutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition
(creator_code:org_t)
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In:Platelets: Informa UK Limited26:6, s. 589-5921369-16350953-7104
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