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Vaccines against en...
Vaccines against enteric infections for the developing world
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Czerkinsky, Cecil, 1953 (author)
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- Holmgren, Jan, 1944 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology
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(creator_code:org_t)
- 2015-06-19
- 2015
- English.
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In: Philosophical Transactions of the Royal Society B-Biological Sciences. - : The Royal Society. - 0962-8436 .- 1471-2970. ; 370:1671
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Abstract
Subject headings
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- Since the first licensure of the Sabin oral polio vaccine more than 50 years ago, only eight enteric vaccines have been licensed for four disease indications, and all are given orally. While mucosal vaccines offer programmatically attractive tools for facilitating vaccine deployment, their development remains hampered by several factors: - limited knowledge regarding the properties of the gut immune system during early life; - lack of mucosal adjuvants, limiting mucosal vaccine development to live-attenuated or killed whole virus and bacterial vaccines; - limited knowledge of the factors contributing to oral vaccine under-performance in children from developing countries. There are now reasons to believe that the development of safe and effective mucosal adjuvants and of programmatically sound intervention strategies could enhance the efficacy of current and next-generation enteric vaccines, especially in lesser developed countries which are often co-endemic for enteric infections and malnutrition. These vaccines must be safe and affordable for the world's poorest, confer long-term protection and herd immunity, and must be able to contain epidemics.
Subject headings
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
Keyword
- enteric
- vaccine
- mucosa
- developing country
- gut
- immunity
- INACTIVATED POLIOVIRUS VACCINE
- ORAL CHOLERA VACCINES
- TYPHOID-FEVER
- ROTAVIRUS VACCINATION
- ANTIBODY-RESPONSES
- DEVELOPING-COUNTRIES
- MUCOSAL
- IMMUNITY
- CONTROLLED-TRIAL
- CELL RESPONSES
- EFFICACY TRIAL
- Biology
Publication and Content Type
- ref (subject category)
- for (subject category)
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