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Decreased secretion...
Decreased secretion of adiponectin through its intracellular accumulation in adipose tissue during tobacco smoke exposure
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Li, M. Z. (author)
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Li, C. J. (author)
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Liu, Y. (author)
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Chen, Y. (author)
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Wu, X. D. (author)
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Yu, D. M. (author)
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Werth, V. P. (author)
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- Williams, Kevin Jon, 1956 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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Liu, M. L. (author)
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(creator_code:org_t)
- 2015-05-09
- 2015
- English.
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In: Nutrition & Metabolism. - : Springer Science and Business Media LLC. - 1743-7075. ; 12
- Related links:
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https://nutritionand...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Background: Cigarette smoking is associated with an increased risk of type 2 diabetes mellitus (T2DM). Smokers exhibit low circulating levels of total adiponectin (ADPN) and high-molecular-weight (HMW) ADPN multimers. Blood concentrations of HMW ADPN multimers closely correlate with insulin sensitivity for handling glucose. How tobacco smoke exposure lowers blood levels of ADPN, however, has not been investigated. In the current study, we examined the effects of tobacco smoke exposure in vitro and in vivo on the intracellular and extracellular distribution of ADPN and its HMW multimers, as well as potential mechanisms. Findings: We found that exposure of cultured adipocytes to tobacco smoke extract (TSE) suppressed total ADPN secretion, and TSE administration to mice lowered their plasma ADPN concentrations. Surprisingly, TSE caused intracellular accumulation of HMW ADPN in cultured adipocytes and in the adipose tissue of wild-type mice, while preferentially decreasing HMW ADPN in culture medium and in plasma. Importantly, we found that TSE up-regulated the ADPN retention chaperone ERp44, which colocalized with ADPN in the endoplasmic reticulum. In addition, TSE down-regulated DsbA-L, a factor for ADPN secretion. Conclusions: Tobacco smoke exposure traps HMW ADPN intracellularly, thereby blocking its secretion. Our results provide a novel mechanism for hypoadiponectinemia, and may help to explain the increased risk of T2DM in smokers.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
Keyword
- Adiponectin
- Tobacco smoke
- Adipocytes
- INSULIN-RESISTANCE
- WEIGHT
- HYPOADIPONECTINEMIA
- MULTIMERIZATION
- MICROVESICLES
- EMPHYSEMA
- MICE
- MEN
- Nutrition & Dietetics
Publication and Content Type
- ref (subject category)
- art (subject category)
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