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Heat stress, dehydr...
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García-Trabanino, Ramón
(author)
Heat stress, dehydration, and kidney function in sugarcane cutters in El Salvador - A cross-shift study of workers at risk of Mesoamerican nephropathy.
- Article/chapterEnglish2015
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LIBRIS-ID:oai:gup.ub.gu.se/220104
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https://gup.ub.gu.se/publication/220104URI
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https://doi.org/10.1016/j.envres.2015.07.007DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:132300165URI
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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An epidemic of progressive kidney failure afflicts sugarcane workers in Central America. Repeated high-intensity work in hot environments is a possible cause. To assess heat stress, dehydration, biomarkers of renal function and their possible associations. A secondary aim was to evaluate the prevalence of pre-shift renal damage and possible causal factors. Sugarcane cutters (N=189, aged 18–49 years, 168 of them male) from three regions in El Salvador were examined before and after shift. Cross-shift changes in markers of dehydration and renal function were examined and associations with temperature, work time, region, and fluid intake were assessed. Pre-shift glomerular filtration rate was estimated (eGFR) from serum creatinine. The mean work-time was 4 (1.4–11) hours. Mean workday temperature was 34–36 °C before noon, and 39–42 °C at noon. The mean liquid intake during work was 0.8 L per hour. There were statistically significant changes across shift. The mean urine specific gravity, urine osmolality and creatinine increased, and urinary pH decreased. Serum creatinine, uric acid and urea nitrogen increased, while chloride and potassium decreased. Pre-shift serum uric acid levels were remarkably high and pre-shift eGFR was reduced (<60 mL/min) in 23 male workers (14%). The high prevalence of reduced eGFR, and the cross-shift changes are consistent with recurrent dehydration from strenuous work in a hot and humid environment as an important causal factor. The pathophysiology may include decreased renal blood flow, high demands on tubular reabsorption, and increased levels of uric acid.
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Jarquín, Emmanuel
(author)
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Wesseling, Catharina
(author)
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Johnson, Richard J
(author)
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González-Quiroz, Marvin
(author)
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Weiss, Ilana
(author)
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Glaser, Jason
(author)
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José Vindell, Juan
(author)
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Stockfelt, Leo,1981Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa, enheten för arbets-och miljömedicin,Institute of Medicine, Department of Public Health and Community Medicine, Section of Occupational and environmental medicine(Swepub:gu)xstole
(author)
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Roncal, Carlos
(author)
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Harra, Tamara
(author)
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Barregård, Lars,1948Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa, enheten för arbets-och miljömedicin,Institute of Medicine, Department of Public Health and Community Medicine, Section of Occupational and environmental medicine(Swepub:gu)xbarrl
(author)
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Göteborgs universitetInstitutionen för medicin, avdelningen för samhällsmedicin och folkhälsa, enheten för arbets-och miljömedicin
(creator_code:org_t)
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In:Environmental research: Elsevier BV142, s. 746-7551096-09530013-9351
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Glaser, Jason
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Environmental re ...
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University of Gothenburg
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Karolinska Institutet