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Human Brown Adipose...
Human Brown Adipose Tissue: What We Have Learned So Far
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Betz, Mattias J. (author)
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- Enerbäck, Sven, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk genetik och klinisk genetik,Institute of Biomedicine, Department of Medical and Clinical Genetics
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(creator_code:org_t)
- 2015-06-07
- 2015
- English.
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In: Diabetes. - : American Diabetes Association. - 0012-1797 .- 1939-327X. ; 64:7, s. 2352-2360
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https://diabetes.dia...
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Abstract
Subject headings
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- Brown adipose tissue (BAT) is a unique tissue that is able to convert chemical energy directly into heat when activated by the sympathetic nervous system. While initially believed to be of relevance only in human newborns and infants, research during recent years provided unequivocal evidence of active BAT in human adults. Moreover, it has become clear that BAT plays an important role in insulin sensitivity in rodents and humans. This has opened the possibility for exciting new therapies for obesity and diabetes. This review summarizes the current state of research with a special focus on recent advances regarding BAT and insulin resistance in human adults. Additionally, we provide an outlook on possible future therapeutic uses of BAT in the treatment of obesity and diabetes.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Keyword
- BETA(3)-ADRENERGIC RECEPTOR AGONIST
- DIET-INDUCED THERMOGENESIS
- ADULT
- HUMANS
- ENERGY-EXPENDITURE
- UNCOUPLING PROTEIN
- WHITE FAT
- OUTDOOR
- TEMPERATURE
- SKELETAL-MUSCLE
- MITOCHONDRIAL BIOGENESIS
- ADAPTIVE
- THERMOGENESIS
- Endocrinology & Metabolism
Publication and Content Type
- ref (subject category)
- art (subject category)
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