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The Triple-Repeat P...
The Triple-Repeat Protein Anakonda Controls Epithelial Tricellular Junction Formation in Drosophila
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- Byri, Sunitha (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin,Institute of Biomedicine
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Misra, T. (author)
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- Syed, Zulfeqhar Ali (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk genetik och klinisk genetik,Institute of Biomedicine, Department of Medical and Clinical Genetics
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Batz, T. (author)
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Shah, J. (author)
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Boril, L. (author)
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Glashauser, J. (author)
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Aegerter-Wilmsen, T. (author)
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Matzat, T. (author)
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Moussian, B. (author)
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- Uv, Anne, 1967 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin,Institute of Biomedicine
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Luschnig, S. (author)
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Ld Vj, Cell V. P. (author)
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(creator_code:org_t)
- Elsevier BV, 2015
- 2015
- English.
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In: Developmental Cell. - : Elsevier BV. - 1534-5807. ; 33:5, s. 535-548
- Related links:
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http://www.cell.com/...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Subject headings
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- In epithelia, specialized tricellular junctions (TCJs) mediate cell contacts at three-cell vertices. TCJs are fundamental to epithelial biology and disease, but only a few TCJ components are known, and how they assemble at tricellular vertices is not understood. Here we describe a transmembrane protein, Anakonda (Aka), which localizes to TCJs and is essential for the formation of tricellular, but not bicellular, junctions in Drosophila. Loss of Aka causes epithelial barrier defects associated with irregular TCJ structure and geometry, suggesting that Aka organizes cell corners. Aka is necessary and sufficient for accumulation of Gliotactin at TCJs, suggesting that Aka initiates TCJ assembly by recruiting other proteins to tricellular vertices. Aka's extracellular domain has an unusual tripartite repeat structure that may mediate self-assembly, directed by the geometry of tricellular vertices. Conversely, Aka's cytoplasmic tail is dispensable for TCJ localization. Thus, extracellular interactions, rather than TCJ-directed intracellular transport, appear to mediate TCJ assembly.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Keyword
- TUBE-SIZE CONTROL
- SEPTATE JUNCTIONS
- BARRIER FUNCTION
- TIGHT JUNCTIONS
- DISCS LARGE
- TRANSMEMBRANE PROTEIN
- TRACHEAL SYSTEM
- NA+/K+ ATPASE
- CELLS
- GLIOTACTIN
- Cell Biology
- Developmental Biology
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Byri, Sunitha
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Misra, T.
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Syed, Zulfeqhar ...
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Batz, T.
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Shah, J.
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Boril, L.
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show more...
-
Glashauser, J.
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Aegerter-Wilmsen ...
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Matzat, T.
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Moussian, B.
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Uv, Anne, 1967
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Luschnig, S.
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Ld Vj, Cell V. P ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
- Articles in the publication
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Developmental Ce ...
- By the university
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University of Gothenburg