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The Alzheimer's Dis...
The Alzheimer's Disease Neuroimaging Initiative 2 Biomarker Core: A review of progress and plans
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Kang, J. H. (author)
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Korecka, M. (author)
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Figurski, M. J. (author)
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Toledo, J. B. (author)
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- Blennow, Kaj, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Zetterberg, Henrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Waligorska, T. (author)
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Brylska, M. (author)
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Fields, L. (author)
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Shah, N. (author)
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Soares, H. (author)
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Dean, R. A. (author)
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Vanderstichele, H. (author)
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Petersen, R. C. (author)
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Aisen, P. S. (author)
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Saykin, A. J. (author)
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Weiner, M. W. (author)
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Trojanowski, J. Q. (author)
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Shaw, L. M. (author)
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(creator_code:org_t)
- 2015-07
- 2015
- English.
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In: Alzheimers & Dementia. - : Wiley. - 1552-5260 .- 1552-5279. ; 11:7, s. 772-791
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Abstract
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- Introduction: We describe Alzheimer's Disease Neuroimaging Initiative (ADNI) Biomarker Core progress including: the Biobank; cerebrospinal fluid (CSF) amyloid beta (A beta(1-42)), t-tau, and p-tau(181) analytical performance, definition of Alzheimer's disease (AD) profile for plaque, and tangle burden detection and increased risk for progression to AD; AD disease heterogeneity; progress in standardization; and new studies using ADNI biofluids. Methods: Review publications authored or coauthored by ADNI Biomarker core faculty and selected non-ADNI studies to deepen the understanding and interpretation ofCSFA beta(1-42), t-tau, and p-tau(181) data. Results: CSFAD biomarker measurements with the qualified AlzBio3 immunoassay detects neuropathologic AD hallmarks in preclinical and prodromal disease stages, based on CSF studies in nonADNI living subjects followed by the autopsy confirmation of AD. Collaboration across ADNI cores generated the temporal ordering model of AD biomarkers varying across individuals because of genetic/environmental factors that increase/decrease resilience to AD pathologies. Discussion: Further studies will refine this model and enable the use of biomarkers studied in ADNI clinically and in disease-modifying therapeutic trials. (C) 2015 Published by Elsevier Inc. on behalf of the Alzheimer's Association.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- Alzheimer's disease
- Mild cognitive impairment
- Cerebrospinal fluid
- Plasma
- Biomarkers
- MILD COGNITIVE IMPAIRMENT
- CEREBROSPINAL-FLUID BIOMARKERS
- PLASMA
- AMYLOID-BETA
- APOLIPOPROTEIN-E GENOTYPE
- TANDEM MASS-SPECTROMETRY
- GENOME-WIDE ASSOCIATION
- CSF BIOMARKERS
- A-BETA
- DIAGNOSTIC GUIDELINES
- Clinical Neurology
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Kang, J. H.
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Korecka, M.
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Figurski, M. J.
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Toledo, J. B.
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Blennow, Kaj, 19 ...
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Zetterberg, Henr ...
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show more...
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Waligorska, T.
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Brylska, M.
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Fields, L.
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Shah, N.
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Soares, H.
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Dean, R. A.
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Vanderstichele, ...
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Petersen, R. C.
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Aisen, P. S.
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Saykin, A. J.
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Weiner, M. W.
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Trojanowski, J. ...
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Shaw, L. M.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
- Articles in the publication
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Alzheimers & Dem ...
- By the university
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University of Gothenburg