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Coupled cell networks are target cells of inflammation, which can spread between different body organs and develop into systemic chronic inflammation
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- Hansson, Elisabeth, 1955 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation
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- Skiöldebrand, Eva (author)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för klinisk kemi och transfusionsmedicin,Institute of Biomedicine, Department of Clinical Chemistry and Transfusion Medicine,Inst för biomedicin och veterinär folkhälsovetenskap,Department of Biomedical Science and Veterinary Public Health
- (creator_code:org_t)
- 2015-07-25
- 2015
- English.
- In: Journal of Inflammation-London. - : Springer Science and Business Media LLC. - 1476-9255. ; 12
- Research review (peer-reviewed)
Abstract
Subject headings
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- Several organs in the body comprise cells coupled into networks. These cells have in common that they are excitable but do not express action potentials. Furthermore, they are equipped with Ca2+ signaling systems, which can be intercellular and/or extracellular. The transport of small molecules between the cells occurs through gap junctions comprising connexin 43. Examples of cells coupled into networks include astrocytes, keratinocytes, chondrocytes, synovial fibroblasts, osteoblasts, connective tissue cells, cardiac and corneal fibroblasts, myofibroblasts, hepatocytes, and different types of glandular cells. These cells are targets for inflammation, which can be initiated after injury or in disease. If the inflammation reaches the CNS, it develops into neuroinflammation and can be of importance in the development of systemic chronic inflammation, which can manifest as pain and result in changes in the expression and structure of cellular components. Biochemical parameters of importance for cellular functions are described in this review.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Läkemedelskemi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medicinal Chemistry (hsv//eng)
Keyword
- Coupled cell networks
- Inflammation
- Pain spreading
- Ca2+ signaling
- Connexin 43
- Gap junctions
- BRAIN ENDOTHELIAL-CELLS
- CENTRAL-NERVOUS-SYSTEM
- NEUROPATHIC PAIN
- ARTICULAR CHONDROCYTES
- GAP-JUNCTIONS
- INTRACELLULAR CA2
- SIGNALING
- PATHWAY
- CALCIUM WAVES
- ATP RELEASE
- IN-VITRO
- Immunology
- ATES OF AMERICA
- V111
- P1316
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