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A Critical Review o...
A Critical Review of Models of Perinatal Infection
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Dean, J. M. (author)
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Shi, Z. J. (author)
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Fleiss, B. (author)
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Gunn, K. C. (author)
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Groenendaal, F. (author)
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van Bel, F. (author)
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Derrick, M. (author)
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Juul, S. E. (author)
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Tan, S. (author)
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Gressens, P. (author)
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- Mallard, Carina, 1963 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology
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Bennet, L. (author)
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Gunn, A. J. (author)
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(creator_code:org_t)
- 2015-02-19
- 2015
- English.
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In: Developmental Neuroscience. - : S. Karger AG. - 0378-5866 .- 1421-9859. ; 37:4-5, s. 289-304
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Abstract
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- One of the central, unanswered questions in perinatology is why preterm infants continue to have such poor long-term neurodevelopmental, cognitive and learning outcomes, even though severe brain injury is now rare. There is now strong clinical evidence that one factor underlying disability may be infection, as well as nonspecific inflammation, during fetal and early postnatal life. In this review, we examine the experimental evidence linking both acute and chronic infection/inflammation with perinatal brain injury and consider key experimental determinants, including the microglia response, relative brain and immune maturity and the pattern of exposure to infection. We highlight the importance of the origin and derivation of the bacterial cell wall component lipopolysaccharide. Such experimental paradigms are essential to determine the precise time course of the inflammatory reaction and to design targeted neuroprotective strategies to protect the perinatal brain from infection and inflammation. (C) 2015 S. Karger AG, Basel
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Prenatal infection
- Postnatal infection
- White matter injury
- Rodents
- Fetal sheep
- Lipopolysaccharide
- WHITE-MATTER INJURY
- PRETERM FETAL SHEEP
- DEVELOPING RAT-BRAIN
- MICROGLIA/MACROPHAGE POLARIZATION DYNAMICS
- OLIGODENDROCYTE LINEAGE
- PROGRESSION
- POSTNATAL SYSTEMIC INFLAMMATION
- CENTRAL-NERVOUS-SYSTEM
- PROGRAMMED CELL-DEATH
- LOW-BIRTH-WEIGHT
- CEREBRAL-PALSY
- Developmental Biology
- Neurosciences
Publication and Content Type
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- By the author/editor
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Dean, J. M.
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Shi, Z. J.
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Fleiss, B.
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Gunn, K. C.
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Groenendaal, F.
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van Bel, F.
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show more...
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Derrick, M.
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Juul, S. E.
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Tan, S.
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Gressens, P.
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Mallard, Carina, ...
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Bennet, L.
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Gunn, A. J.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Developmental Ne ...
- By the university
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University of Gothenburg