A Critical Review of Models of Perinatal Infection

One of the central, unanswered questions in perinatology is why preterm infants continue to have such poor long-term neurodevelopmental, cognitive and learning outcomes, even though severe brain injury is now rare. There is now strong clinical evidence that one factor underlying disability may be infection, as well as nonspecific inflammation, during fetal and early postnatal life. In this review, we examine the experimental evidence linking both acute and chronic infection/inflammation with perinatal brain injury and consider key experimental determinants, including the microglia response, relative brain and immune maturity and the pattern of exposure to infection. We highlight the importance of the origin and derivation of the bacterial cell wall component lipopolysaccharide. Such experimental paradigms are essential to determine the precise time course of the inflammatory reaction and to design targeted neuroprotective strategies to protect the perinatal brain from infection and inflammation. (C) 2015 S. Karger AG, Basel

MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Neurovetenskaper hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Neurosciences hsv//eng
Prenatal infection
Postnatal infection
White matter injury
Rodents
Fetal sheep
Lipopolysaccharide
WHITE-MATTER INJURY
PRETERM FETAL SHEEP
DEVELOPING RAT-BRAIN
MICROGLIA/MACROPHAGE POLARIZATION DYNAMICS
OLIGODENDROCYTE LINEAGE
PROGRESSION
POSTNATAL SYSTEMIC INFLAMMATION
CENTRAL-NERVOUS-SYSTEM
PROGRAMMED CELL-DEATH
LOW-BIRTH-WEIGHT
CEREBRAL-PALSY
Developmental Biology
Neurosciences

Shi, Z. J. (author)
Fleiss, B. (author)
Gunn, K. C. (author)
Groenendaal, F. (author)
van Bel, F. (author)
Derrick, M. (author)
Juul, S. E. (author)
Tan, S. (author)
Gressens, P. (author)
Mallard, Carina,1963Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology(Swepub:gu)xmallc (author)
Bennet, L. (author)
Gunn, A. J. (author)
Göteborgs universitetInstitutionen för neurovetenskap och fysiologi (creator_code:org_t)

By the author/editor: Dean, J. M.; Shi, Z. J.; Fleiss, B.; Gunn, K. C.; Groenendaal, F.; van Bel, F.; show more...; Derrick, M.; Juul, S. E.; Tan, S.; Gressens, P.; Mallard, Carina, ...; Bennet, L.; Gunn, A. J.; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Neurosciences

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