Search: onr:"swepub:oai:gup.ub.gu.se/221883" >
Quantifying Diet-In...
-
Shoaie, Saeed,1985Chalmers tekniska högskola,Chalmers University of Technology,Inserm Transfert SA,Assistance publique – Hôpitaux de Paris (AP-HP)
(author)
Quantifying Diet-Induced Metabolic Changes of the Human Gut Microbiome
- Article/chapterEnglish2015
Publisher, publication year, extent ...
Numbers
-
LIBRIS-ID:oai:gup.ub.gu.se/221883
-
https://gup.ub.gu.se/publication/221883URI
-
https://doi.org/10.1016/j.cmet.2015.07.001DOI
-
https://research.chalmers.se/publication/221883URI
Supplementary language notes
Part of subdatabase
Classification
-
Subject category:ref swepub-contenttype
-
Subject category:art swepub-publicationtype
Notes
-
The human gut microbiome is known to be associated with various human disorders, but a major challenge is to go beyond association studies and elucidate causalities. Mathematical modeling of the human gut microbiome at a genome scale is a useful tool to decipher microbe-microbe, diet-microbe and microbe-host interactions. Here, we describe the CASINO (Community And Systems-level INteractive Optimization) toolbox, a comprehensive computational platform for analysis of microbial communities through metabolic modeling. We first validated the toolbox by simulating and testing the performance of single bacteria and whole communities in vitro. Focusing on metabolic interactions between the diet, gut microbiota, and host metabolism, we demonstrated the predictive power of the toolbox in a diet-intervention study of 45 obese and overweight individuals and validated our predictions by fecal and blood metabolomics data. Thus, modeling could quantitatively describe altered fecal and serum amino acid levels in response to diet intervention.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Ghaffari Nouran, Pouyan,1980Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)ghaffari
(author)
-
Kovatcheva-Datchary, PetiaGothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberglaboratoriet,Institute of Medicine, Department of Molecular and Clinical Medicine,Wallenberg Laboratory,University of Gothenburg(Swepub:gu)xkovpe
(author)
-
Mardinoglu, Adil,1982Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)adilm
(author)
-
Sen, Partho,1983Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)sarathi
(author)
-
Pujos-Guillot, E.INRA Centre de Clermont-Ferrand-Theix
(author)
-
de Wouters, T.Microbiologie de l'Alimentation au Service de la Sante Humaine
(author)
-
Juste, C.Microbiologie de l'Alimentation au Service de la Sante Humaine,Imperial College of Science, Technology and Medicine
(author)
-
Rizkalla, S.
(author)
-
Chilloux, J.
(author)
-
Hoyles, L.Imperial College of Science, Technology and Medicine
(author)
-
Nicholson, J. K.Imperial College of Science, Technology and Medicine
(author)
-
Dore, J.Microbiologie de l'Alimentation au Service de la Sante Humaine
(author)
-
Dumas, M. E.Imperial College of Science, Technology and Medicine
(author)
-
Clement, K.Assistance publique – Hôpitaux de Paris (AP-HP),Inserm Transfert SA
(author)
-
Bäckhed, Fredrik,1973Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberglaboratoriet,Institute of Medicine, Department of Molecular and Clinical Medicine,Wallenberg Laboratory,Köpenhamns universitet,University of Copenhagen,University of Gothenburg(Swepub:gu)xbafre
(author)
-
Nielsen, Jens B,1962Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)nielsenj
(author)
-
Chalmers tekniska högskolaInserm Transfert SA
(creator_code:org_t)
Related titles
-
In:Cell Metabolism: Elsevier BV22:2, s. 320-3311550-41311932-7420
Internet link
Find in a library
To the university's database
- By the author/editor
-
Shoaie, Saeed, 1 ...
-
Ghaffari Nouran, ...
-
Kovatcheva-Datch ...
-
Mardinoglu, Adil ...
-
Sen, Partho, 198 ...
-
Pujos-Guillot, E ...
-
show more...
-
de Wouters, T.
-
Juste, C.
-
Rizkalla, S.
-
Chilloux, J.
-
Hoyles, L.
-
Nicholson, J. K.
-
Dore, J.
-
Dumas, M. E.
-
Clement, K.
-
Bäckhed, Fredrik ...
-
Nielsen, Jens B, ...
-
show less...
- About the subject
-
- NATURAL SCIENCES
-
NATURAL SCIENCES
-
and Biological Scien ...
-
and Cell Biology
- Articles in the publication
-
Cell Metabolism
- By the university
-
University of Gothenburg
-
Chalmers University of Technology