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  • Nyandoro, Stephen S.,1975 (author)

N-Cinnamoyltetraketide Derivatives from the Leaves of Toussaintia orientalis

  • Article/chapterEnglish2015

Publisher, publication year, extent ...

  • 2015-07-27
  • American Chemical Society (ACS),2015

Numbers

  • LIBRIS-ID:oai:gup.ub.gu.se/222625
  • https://gup.ub.gu.se/publication/222625URI
  • https://doi.org/10.1021/acs.jnatprod.5b00356DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-356007URI

Supplementary language notes

  • Language:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Seven N-cinnamoyltetraketides (1–7), including the new Z-toussaintine E (2), toussaintine F (6), and toussaintine G (7), were isolated from the methanol extract of the leaves of Toussaintia orientalis using column chromatography and HPLC. The configurations of E-toussaintine E (1) and toussaintines A (3) and D (5) are revised based on single-crystal X-ray diffraction data from racemic crystals. Both the crude methanol extract and the isolated constituents exhibit antimycobacterial activities (MIC 83.3–107.7 μM) against the H37Rv strain of Mycobacterium tuberculosis. Compounds 1, 3, 4, and 5 are cytotoxic (ED50 15.3–105.7 μM) against the MDA-MB-231 triple negative aggressive breast cancer cell line.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Ndanu, J.,1970 (author)
  • Munissi, Joan J. E.,1976 (author)
  • Gruhonjic, AmraGothenburg University,Göteborgs universitet,Sahlgrenska Cancer Center (author)
  • Fitzpatrick, Paul A.Gothenburg University,Göteborgs universitet,Sahlgrenska Cancer Center(Swepub:gu)xfitpa (author)
  • Landberg, Göran,1963Gothenburg University,Göteborgs universitet,Sahlgrenska Cancer Center(Swepub:gu)xlgora (author)
  • Lu, You,1980 (author)
  • Wang, B.,1980 (author)
  • Pan, F.,1980 (author)
  • Rissanen, K.,1960 (author)
  • Erdelyi, Mate,1975Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Svenskt NMR-centrum vid Göteborgs universitet,Department of Chemistry and Molecular Biology,Swedish NMR Centre at Göteborg University,organisk kemi(Swepub:uu)mateerde (author)
  • Lu, Yu (author)
  • Göteborgs universitetSahlgrenska Cancer Center (creator_code:org_t)

Related titles

  • In:Journal of natural products: American Chemical Society (ACS)78:8, s. 2045-20500163-38641520-6025

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