Cutting Edge: Retinoic Acid Signaling in B Cells Is Essential for Oral Immunization and Microflora Composition

Pantazi, E. (author)

Marks, Ellen, 1982 (author)

Stolarczyk, E. (author)

Lycke, Nils Y, 1954 (author): Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology

Noelle, R. J. (author)

Elgueta, R. (author)

(creator_code:org_t)

2015-08-15
2015
English.
In: Journal of Immunology. - : The American Association of Immunologists. - 0022-1767 .- 1550-6606. ; 195:4, s. 1368-1371

Related links:: https://www.jimmunol...; show more...; https://gup.ub.gu.se...; https://doi.org/10.4...; show less...

Abstract Subject headings

Retinoic acid (RA) is a critical regulator of the intestinal adaptive immune response. However, the intrinsic impact of RA on B cell differentiation in the regulation of gut humoral immunity in vivo has never been directly shown. To address this issue, we have been able to generate a mouse model where B cells specifically express a dominant-negative receptor a for RA. In this study, we show that the silencing of RA signaling in B cells reduces the numbers of IgA(+) Ab-secreting cells both in vitro and in vivo, suggesting that RA has a direct effect on IgA plasma cell differentiation. Moreover, the lack of RA signaling in B cells abrogates Ag-specific IgA responses after oral immunization and affects the microbiota composition. In conclusion, these results suggest that RA signaling in B cells through the RA receptor a is important to generate an effective gut humoral response and to maintain a normal microbiota composition.

By the author/editor: Pantazi, E.; Marks, Ellen, 19 ...; Stolarczyk, E.; Lycke, Nils Y, 1 ...; Noelle, R. J.; Elgueta, R.

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Immunology in th ...

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