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  • Kimbung, SikerLund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine (author)

Contrasting breast cancer molecular subtypes across serial tumor progression stages: biological and prognostic implications.

  • Article/chapterEnglish2015

Publisher, publication year, extent ...

  • 2015-09-08
  • Impact Journals, LLC,2015

Numbers

  • LIBRIS-ID:oai:gup.ub.gu.se/222996
  • https://gup.ub.gu.se/publication/222996URI
  • https://doi.org/10.18632/oncotarget.5089DOI
  • https://lup.lub.lu.se/record/8039009URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:132313338URI

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  • Language:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • The relevance of the intrinsic subtypes for clinical management of metastatic breast cancer is not comprehensively established. We aimed to evaluate the prevalence and prognostic significance of drifts in tumor molecular subtypes during breast cancer progression. A well-annotated cohort of 304 women with advanced breast cancer was studied. Tissue microarrays of primary tumors and synchronous lymph node metastases were constructed. Conventional biomarkers were centrally assessed and molecular subtypes were assigned following the 2013 St Gallen guidelines. Fine-needle aspirates of asynchronous metastases were transcriptionally profiled and subtyped using PAM50. Discordant expression of individual biomarkers and molecular subtypes was observed during tumor progression. Primary luminal-like tumors were relatively unstable, frequently adopting a more aggressive subtype in the metastases. Notably, loss of ER expression and a luminal to non-luminal subtype conversion was associated with an inferior post-recurrence survival. In addition, ER and molecular subtype assessed at all tumor progression stages were independent prognostic factors for post-recurrence breast cancer mortality in multivariable analyses. Our results demonstrate that drifts in tumor molecular subtypes may occur during tumor progression, conferring adverse consequences on outcome following breast cancer relapse.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Kovács, Anikó,1961 (author)
  • Danielsson, Anna,1973Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för onkologi,Institute of Clinical Sciences, Department of Oncology(Swepub:gu)xdanne (author)
  • Bendahl, Pär-OlaLund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)onk-pbe (author)
  • Lövgren, KristinaLund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)onk-klo (author)
  • Stolt, Marianne Frostvik (author)
  • Tobin, Nicholas PKarolinska Institutet (author)
  • Lindström, LindaKarolinska Institutet (author)
  • Bergh, JonasKarolinska Institutet (author)
  • Einbeigi, Zakaria,1962Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för onkologi,Institute of Clinical Sciences, Department of Oncology(Swepub:gu)xeinza (author)
  • Fernö, MårtenLund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)onk-mfe (author)
  • Hatschek, ThomasKarolinska Institutet (author)
  • Hedenfalk, IngridLund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)onk-ifa (author)
  • Bröstcancer-genetikSektion I (creator_code:org_t)

Related titles

  • In:Oncotarget: Impact Journals, LLC6:32, s. 33306-181949-2553

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