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World Workshop on O...
World Workshop on Oral Medicine VI: a systematic review of medication-induced salivary gland dysfunction: prevalence, diagnosis, and treatment
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Villa, A. (author)
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Wolff, A. (author)
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Aframian, D. (author)
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Vissink, A. (author)
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- Ekström, Jörgen, 1944 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för farmakologi,Institute of Neuroscience and Physiology, Department of Pharmacology
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Proctor, G. (author)
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McGowan, R. (author)
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Narayana, N. (author)
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Aliko, A. (author)
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Sia, Y. W. (author)
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Joshi, R. K. (author)
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Jensen, S. B. (author)
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Kerr, A. R. (author)
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Dawes, C. (author)
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Pedersen, A. M. L. (author)
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(creator_code:org_t)
- 2015-05-22
- 2015
- English.
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In: Clinical Oral Investigations. - : Springer Science and Business Media LLC. - 1432-6981 .- 1436-3771. ; 19:7, s. 1563-1580
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Abstract
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- Objectives Medication-induced salivary gland dysfunction (MISGD) causes significant morbidity resulting in decreased quality of life. This systematic review assessed the literature on the prevalence, diagnosis, treatment, and prevention of MISGD. Materials and methods Electronic databases were searched for articles related to MISGD through June 2013. Four independent reviewers extracted information regarding study design, study population, interventions, outcomes, and conclusions for each article. Only papers with acceptable degree of relevance, quality of methodology, and strength of evidence were retained for further analysis. Results There were limited data on the epidemiology of MISGD. Furthermore, various methods were used to assess salivary flow rate or xerostomia. Preventive and therapeutic strategies included substitution of medications, oral, or systemic therapy with sialogogues, use of saliva substitutes or of electro-stimulating devices. Although there are promising approaches to improve salivary gland function, most studies are characterized by small numbers and heterogeneous methods. Conclusions Physicians and dentists should identify the medications associated with xerostomia and salivary gland dysfunction through a thorough medical history. Preferably, health care providers should measure the unstimulated and stimulated whole salivary flow rates of all their patients so that these values can be used as a baseline to rate the complaints of patients who subsequently claim to experience xerostomia or salivary gland dysfunction as well as the possibilities of effectively treating this condition. Clinical relevance MISGD remains a major burden for the population. This systematic review provides a contemporary in-depth description of the diagnosis and treatment of MISGD.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Odontologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dentistry (hsv//eng)
Keyword
- Xerostomia
- Saliva
- Medications
- Salivary gland dysfunction
- PRIMARY SJOGRENS-SYNDROME
- DRUG-INDUCED XEROSTOMIA
- RAT PAROTID-GLAND
- INDUCED DRY MOUTH
- FLOW-RATES
- DOUBLE-BLIND
- PILOCARPINE TREATMENT
- CLINICAL-TRIAL
- PSYCHIATRIC-PATIENTS
- SUBJECTIVE REPORTS
- Dentistry
- Oral Surgery & Medicine
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Villa, A.
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Wolff, A.
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Aframian, D.
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Vissink, A.
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Ekström, Jörgen, ...
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Proctor, G.
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show more...
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McGowan, R.
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Narayana, N.
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Aliko, A.
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Sia, Y. W.
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Joshi, R. K.
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Jensen, S. B.
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Kerr, A. R.
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Dawes, C.
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Pedersen, A. M. ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Dentistry
- Articles in the publication
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Clinical Oral In ...
- By the university
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University of Gothenburg