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α-Imaging Confirmed Efficient Targeting of CD45-Positive Cells After 211At-Radioimmunotherapy for Hematopoietic Cell Transplantation.

Frost, Sofia, 1981 (author)
Miller, Brian W (author)
Bäck, Tom, 1964 (author)
Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för radiofysik,Institute of Clinical Sciences, Department of Radiation Physics
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Santos, Erlinda B (author)
Hamlin, Donald K (author)
Knoblaugh, Sue E (author)
Frayo, Shani L (author)
Kenoyer, Aimee L (author)
Storb, Rainer (author)
Press, Oliver W (author)
Wilbur, D Scott (author)
Pagel, John M (author)
Sandmaier, Brenda M (author)
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 (creator_code:org_t)
2015-09-03
2015
English.
In: Journal of nuclear medicine : official publication, Society of Nuclear Medicine. - : Society of Nuclear Medicine. - 1535-5667. ; 56:11, s. 1766-1773
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Alpha-radioimmunotherapy targeting CD45 may substitute for total body irradiation in hematopoietic cell transplantation (HCT) preparative regimens for lymphoma. Our goal was to optimize the anti-CD45 monoclonal antibody (MAb; CA12.10C12) protein dose for astatine-211 ((211)At)-radioimmunotherapy, extending the analysis to include intra-organ (211)At activity distribution and α-imaging-based small-scale dosimetry, along with immunohistochemical staining.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)

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