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Using QCM-D to stud...
Using QCM-D to study the adhesion of human gingival fibroblasts on implant surfaces
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- Westas, Emma, 1982 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Svanborg, L. M. (author)
- Malmö högskola,Odontologiska fakulteten (OD)
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- Wallin, Patric, 1985 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Bauer, Brigitte, 1978 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology,University of Gothenburg
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- Ericson, Marica B, 1974 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology
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- Wennerberg, Ann (author)
- Malmö högskola,Odontologiska fakulteten (OD)
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- Mustafa, K. (author)
- Universitetet i Bergen,University of Bergen
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- Andersson, Martin, 1974 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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(creator_code:org_t)
- 2015-03-26
- 2015
- English.
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In: Journal of Biomedical Materials Research. Part A. - : Wiley. - 1549-3296 .- 1552-4965. ; 103:10, s. 3139-3147
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Abstract
Subject headings
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- Sealing the soft tissue-implant interface is one of the key issues in preventing transcutaneous implant-associated infections. A promising surface modification for improving osseointegration and possibly soft tissue integration is to coat the implant surface with hydroxyapatite (HA) nanoparticles. When new implant materials are developed, their ability to facilitate cell attachment and spreading are commonly investigated in vitro to establish their potential for good in vivo performance. However, commonly used techniques, such as microscopy methods, are time consuming, invasive, and subjective. This is the first study using quartz crystal microbalance with dissipation monitoring, where the real-time adhesion of biopsy-derived human gingival fibroblasts onto titanium and nanostructured HA was investigated. Experiments were performed for at least 16 h, and we found that cellular attachment and spreading kinetics can be followed in situ by observing the change in dissipation and frequency with time. Interestingly, a correlation between cell coverage and the magnitude of dissipation shift reached at the end of the experiment was found, but no such trend was observed for the frequency. Furthermore, the level of cell coverage was found to influence the cellular attachment and spreading behavior. No difference in cell response to the two surface types, Ti and nanostructured HA, was found.
Subject headings
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
- NATURVETENSKAP -- Biologi -- Mikrobiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Microbiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Odontologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dentistry (hsv//eng)
Keyword
- QCM-D
- gingival fibroblasts
- nanomaterials
- hydroxyapatite
- titanium
- titanium
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Westas, Emma, 19 ...
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Svanborg, L. M.
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Wallin, Patric, ...
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Bauer, Brigitte, ...
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Ericson, Marica ...
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Wennerberg, Ann
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show more...
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Mustafa, K.
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Andersson, Marti ...
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show less...
- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Microbiology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Dentistry
- Articles in the publication
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Journal of Biome ...
- By the university
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University of Gothenburg
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Chalmers University of Technology
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Malmö University